Shenzhen Third People’s Hospital

Infection of macrophages by mpox virus activates inflammasome and cell death, informing multitarget therapeutic strategies

Severe mpox virus (MPXV) infection causes immunopathological manifestations in patients. Here, we provide clinical evidence of MPXV-induced inflammation in a large patient cohort and demonstrate direct macrophage infection in skin tissues from an autopsied mpox patient. In human...

Timing of surgery for a melioidosis-associated abdominal aortic pseudoaneurysm: a case report

BACKGROUND: Melioidosis is a tropical infectious disease caused by Burkholderia pseudomallei. Although vascular involvement is rare, melioidosis-associated abdominal aortic pseudoaneurysm can rapidly progress and carries a high risk of rupture and mortality. Due to nonspecific ea...

Interleukin-15-armed trivalent mRNA vaccine elicits robust and durable protection against lethal mpox and vaccinia virus challenges in mice

The global re-emergence of mpox virus (MPXV) poses a critical threat, particularly to vulnerable immunocompromised populations, thus highlighting an urgent need for effective and safe interventions. In this study, we developed and compared three mRNA-LNP candidates: a trivalent c...

Nano-NucleOTAC-mediated Z-DNA transformation disrupts mycobacterium tuberculosis biofilms and activates antibacterial immunity

The biofilms of Mycobacterium Tuberculosis (Mtb) use extracellular DNA (eDNA) as a protective structural scaffold that shields resident bacteria from host immunity and antibiotics, promoting persistent infection. An FDA-approved DNase can partially hydrolyze eDNA but has limited...

Construction and validation of a diagnostic model for interventricular septal hypertrophy based on electrocardiographic parameters and clinical factors

Interventricular septal hypertrophy (IVSH) is considered to be an early-stage alteration of left ventricular hypertrophy and is a major risk factor for a wide range of fatal arrhythmias and heart failure. We aimed to develop and validate a diagnostic model to detect patients with...

Identification of RAB36 and NINL as potential diagnostic biomarkers for gestational diabetes mellitus and polycystic ovary syndrome

Gestational diabetes mellitus (GDM) and polycystic ovary syndrome (PCOS) are common endocrine and metabolic disorders in women, with PCOS increasing the risk of GDM. However, shared molecular markers that could support early diagnosis and the mechanisms underlying them remain ins...

Longitudinal spatial multi-omics delineates tumor microenvironment remodeling across sequential EGFR-TKIs in EGFR-mutant NSCLC

Abstract Background Resistance to therapy is a frequent occurrence in patients with epidermal growth factor receptor (EGFR)-mutant non-small-cell lung cancer (NSCLC) who are treated with EGFR tyrosine kinase inhibitors (EGFR-TKIs). However, spatial information on how the tumor mi...

Functional characterization of a pore‐forming effector TseMt from the H4 type VI secretion system of Pseudomonas aeruginosa

Abstract Pseudomonas aeruginosa is a major nosocomial pathogen in which the type VI secretion system (T6SS) contributes to interbacterial competition and virulence. While most strains encode three T6SSs, additional T6SS clusters have been identified in clinical isolates through c...

Mechanism and plasticity of primitive pyroptosis

Pyroptosis is a proinflammatory form of regulated cell death across the tree of life. The gasdermin (GSDM) protein family functions as an evolutionarily conserved executioner of pyroptotic cell death by forming membrane pores. As the canonical activation mechanism, proteolytic cl...

Pan-retinal pathology detection in oct scans integrating natural language synthesis with diagnostic annotation

Abstract While OCT is pivotal for macular disease diagnosis, its adoption in primary care is limited by AI systems that cannot simultaneously analyze multi-sectional scans across the full spectrum of maculopathies or generate diagnostically integrated reports. Here we present iOC...