Shenzhen Ruipuxun Academy for Stem Cell & Regenerative Medicine

ZCCHC4 promotes replication-dependent histone mRNA translation through interaction with the eIF3 complex

Abstract Histone synthesis is tightly coupled with DNA replication to ensure proper chromatin assembly and genome stability. To meet the sharply elevated demand for histones during S phase, eukaryotic cells employ specialized mechanisms to translate replication-dependent (RD) his...