Shenzhen Pingle Orthopedic Hospital

Comparative efficacy and safety of PCSK9 inhibitors for lipoprotein(a) reduction: a systematic review and network meta−analysis

Abstract Introduction Lipoprotein(a) [Lp(a)] is a genetically determined cardiovascular risk factor that is largely unaffected by statins. Although PCSK9 inhibitors can lower Lp(a), comparative evidence among agents is limited. Methods We conducted a systematic review and frequen...

Clinical value of hsa_circ_0003254 in postmenopausal osteoporosis and its role in the progression of osteoporosis

Objective Circular RNAs (circRNAs) are important regulators of human disease, yet their specific mechanistic role in postmenopausal osteoporosis (PMOP) remains unclear. This study aimed to investigate the expression pattern, diagnostic value, and biological function of hsa_circ_0...

Association of methylenetetrahydrofolate reductase C677T polymorphism with lacunar infarction: A systematic review and meta-analysis

Background: The association between the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and lacunar infarction (LI) remains inconclusive. Methods: The literature retrieval encompassed PubMed, EMBASE, Cochrane Library, China National Knowledge Infrastructure, and Wa...

The TLR9-CXCL2 complex orchestrates mitochondrial DNA-driven regulatory B cell dysfunction in acute lung injury

Acute lung injury (ALI)/Acute respiratory distress syndrome (ARDS) is a lethal condition driven by unresolved inflammation. Circulating mitochondrial DNA (mtDNA) acts as a potent damage-associated molecular pattern, yet its direct role in disrupting adaptive immune checkpoints re...

Unraveling the hormonal causality in postpartum depression: findings from a two-sample Mendelian randomization study

OBJECTIVES: Postpartum depression (PPD) profoundly affects maternal health and disrupts mother-infant bonding, with lasting effects on infant development. The causal roles of hormones that change most dramatically during the perinatal period, including estradiol, cortisol, and pr...