ShenZhen People’s Hospital

Peritumoral Malignant Cellular Foci Performs Better Than Tumor Budding and Poorly Differentiated Cluster in Risk Stratification of Lymph Node Metastasis in pT1 Colorectal Cancer

As biomarkers separated by the arbitrary 5-tumor-cell cutoff at the tumor invasive front, tumor budding (TB) and poorly differentiated clusters (PDC) are recognized as high-risk factors for lymph node metastasis (LNM) in pT1 colorectal cancer (CRC). Nonetheless, relevant findings...

Effectiveness and Safety of Fixed‐Dose Combination Metformin and Empagliflozin in Type 2 Diabetes: A Prospective, Multicenter, Real‐World Study From China

BACKGROUND: This study assessed the real-world effectiveness and safety of a fixed-dose combination (FDC) of metformin and empagliflozin in Chinese patients with type 2 diabetes mellitus (T2DM). METHODS: This prospective, multicenter, real-world study enrolled consecutive patient...

In Situ detection of protein-phosphoinositide signalosome in tissues by immunohistochemistry-coupled proximity ligation assay

Abstract Phosphoinositides (PIPs) are central lipid signaling molecules, with PtdIns(3,4,5)P 3 acting as a key regulator of the PI3K-AKT pathway and a major driver of tumorigenesis. Together with p53 mutations or loss, this pathway represents one of the most frequently dysregulat...

Baicalein Ameliorates Postmenopausal Osteoporosis With Iron Accumulation by Inhibiting Osteoclastogenesis via Nrf2 Activation

ABSTRACT Postmenopausal osteoporosis (PMOP) is frequently complicated by iron accumulation, which exacerbates bone loss. Baicalein, a natural flavonoid with iron‐chelating and antioxidant properties, has shown bone‐protective effects, but its role in iron‐overloaded PMOP remains...

A canonical role of SMAD4 in safeguarding 3D genome architecture to suppress lung tumorigenesis

Dysregulation of three-dimensional (3D) genome architecture is a hallmark of cancer, yet the mechanisms by which its disruption drives tumorigenesis remain incompletely understood. Here, we demonstrated that SMAD4 regulated 3D genome organization through its canonical transcripti...

Automated Multimodal Correlative Registration for Organelle-Specific Elemental and Isotopic Imaging

Abstract Mapping the subcellular partitioning of therapeutics is important for understanding their trafficking, mechanisms of action, and off-target effects. NanoSIMS provides chemical images of labeled therapeutics, but assigning these signals to cellular structures requires cor...

Application of palliative tunneled patient-controlled epidural analgesia in children with refractory cancer-related visceral pain and breakthrough pain: case report

Managing refractory cancer-related pain in pediatric patients with terminal-stage malignancies presents significant challenges, particularly when complicated by intestinal obstruction and cachexia. Conventional systemic analgesics often prove inadequate or intolerable. A 10-year-...

Clinical outcomes and molecular features of CEBPA-mutated MPAL: a multi-center case series

Mixed phenotype acute leukemia (MPAL) is rare and aggressive, with no standard therapy. CEBPA mutations define favorable-risk AML, but their significance in MPAL is unknown. We reviewed eight CEBPA -mutated MPAL patients from five Chinese centers. Four received allo-HSCT in first...

Longitudinal plasma phosphorylated tau217 classification and the association with Alzheimer's disease progression

Abstract INTRODUCTION Longitudinal diagnostic and prognostic validity of plasma phosphorylated tau217 (p‐tau217) in Alzheimer's disease (AD) remains uncertain. METHODS In this multi‐cohort study of 2117 individuals, we established baseline plasma p‐tau217 thresholds for amyloid‐β...

Papillary urothelial neoplasm of low malignant potential: real-world diagnostic pitfalls and clinical outcomes from a case series

Papillary urothelial neoplasm of low malignant potential (PUNLMP) is an uncommon non-muscle-invasive bladder tumor. Its indolent nature often leads to underestimation of diagnostic complexity and recurrence risk, particularly in real-world practice where pathological distinction...

An explainable biomedical foundation model via large-scale concept-enhanced vision–language pretraining

Artificial intelligence for medical imaging is required to be accurate and interpretable to clinicians. However, current multimodal biomedical foundation models often prioritize performance over explainability. Here we present ConceptCLIP, an explainable biomedical foundation mod...

Hemoglobin-Red Blood Cell Distribution Width Ratio (HRR) and Rheumatoid Arthritis Risk: A Population-Based Study from the NHANES

Abstract Background: Rheumatoid arthritis (RA) is a prevalent autoimmune disease with a substantial health burden. The Hemoglobin-red cell distribution width ratio (HRR) is a novel inflammation-related biomarker, yet its association with RA risk remains unexplored. Aims: This stu...

YAP delactylation enhances therapy resistance in renal cell carcinoma

Abstract Lactylation is a novel lysine acylation modification, and its function and exact mechanisms remain unclear. The responsiveness to combined targeted and immunotherapy continues to be a major challenge in cancer treatment. Here, we discovered that lysine lactylation (Kla)...

Clinical utility of molecular residual disease detection in early-stage resected EGFR-mutated non-small cell lung cancer

Molecular residual disease (MRD), detected through circulating tumor DNA, has emerged as a promising biomarker for surveillance in patients with early-stage non-small cell lung cancer (NSCLC) following curative-intent resection. Here we report the MRD analysis from the phase 3 EV...