Shenzhen Maternity and Child Healthcare Hospital

Clinical Performance Evaluation of Size‐Selective Placental Cell‐Free DNA Enrichment for Non‐Invasive Prenatal Testing of Fetal Copy Number Variants

ABSTRACT Objective To evaluate the performance of low‐depth non‐invasive prenatal testing (NIPT) using cell‐free DNA enrichment for detecting fetal copy number variations (CNVs) and to assess its clinical utility. Methods A retrospective analysis was conducted on 86,012 pregnant...

Engineered exosome MDC@Ex-γ3-CeO₂@PDA for multi-target therapy of sepsis-induced acute lung injury

Sepsis-induced acute lung injury (ALI), with a complex pathogenesis, currently lacks clinically effective multi-target therapeutic strategies. Musca domestica cecropin (MDC), a promising antimicrobial, anti-inflammatory, and endothelial-repairing peptide, is limited by its high m...

Circulating RANKL is required for glucose homeostasis during pregnancy

Gestational diabetes mellitus (GDM) poses a significant health burden on women worldwide, necessitating the search for predictive, diagnostic and therapeutic approaches. Increasing evidence suggests that the receptor activator of NF-κB ligand (RANKL) is closely associated with GD...

Vaginal microbiome and metabolome profiling identifies candidate signatures associated with persistent high-risk HPV infection

Abstract The role of vaginal microbiota dysbiosis in the progression of human papillomavirus (HPV) infection is increasingly recognized. Yet, the factors determining why only a minority of infections persist and evolve into clinically significant disease remain poorly defined. Fr...

Defective PDZK1 palmitoylation impairs epididymosome-mediated cholesterol transport and contributes to asthenozoospermia

Asthenozoospermia, a leading cause of male infertility characterized by impaired sperm motility, involves dysregulated cholesterol efflux during epididymal maturation, yet the underlying mechanisms remain elusive. Here, we demonstrate that PDZK1 protein level and its palmitoylati...

Associations of Ureaplasma status with early white blood cell count and interstitial radiographic changes in extremely preterm infants by gestational age

Ureaplasma species (spp.) have been associated with changes in white blood cell (WBC) count and radiographic abnormalities in preterm infants, but whether these associations differ according to gestational age (GA) remains unclear. This study aimed to evaluate whether GA modifies...

Construction and validation of a diagnostic model for interventricular septal hypertrophy based on electrocardiographic parameters and clinical factors

Interventricular septal hypertrophy (IVSH) is considered to be an early-stage alteration of left ventricular hypertrophy and is a major risk factor for a wide range of fatal arrhythmias and heart failure. We aimed to develop and validate a diagnostic model to detect patients with...

Hybrid long-read sequencing reveals genomic homogeneity, blaZ copy-number variation, and phenotypic adaptation of the emerging Asian ST188 MSSA lineage from pediatric gut and vaginal colonization sites, Southern China

Staphylococcus aureus ( S. aureus ) ST188 has emerged as an important methicillin-susceptible clonal lineage in Asia and is frequently associated with human colonization and community-acquired infections. This study investigates ST188 isolates from aerobic vaginitis and pediatric...

LiteFDNet: A Lightweight Deep Network for Cardiotocography-Based Fetal Distress Detection

This retrospective single-center study developed and evaluated LiteFDNet, a lightweight deep neural network for intrapartum fetal distress detection from cardiotocography (CTG). All eligible deliveries from April 2014 to December 2024 were included under IRB approval (LGECH-2023-...

Benzo[a]pyrene-induced METTL3 overexpression accelerates renal cell carcinoma progression via m6A modification of LTB4R mRNA and enhanced Treg infiltration

Benzo[ a ]pyrene (BaP) is a widespread environmental pollutant and a representative polycyclic aromatic hydrocarbon with well-established carcinogenic properties. However, the molecular mechanisms through which BaP promotes renal cell carcinoma (RCC) progression, particularly tho...

EFAU-Net: efficient feature-enhanced U-Net for early pregnancy ultrasound segmentation

Early-pregnancy ultrasound images often contain gestational sac, yolk sac, and embryo regions with blurred boundaries, variable shapes, and small target sizes, which makes accurate segmentation difficult. In addition, many existing segmentation networks have high computational co...

Fetal brain five-axial planes and 3D-ICRV cerebral surface imaging from 16 to 36 weeks of gestation

Abstract Background Recent advances in fetal neurosonography have increased interest in prenatal cortical assessment. However, the transvaginal approach, while providing superior resolution, is technically complex and limited to specialized settings. Methods This study utilizes a...