Shenzhen Luohu People's Hospital

Seismic performance of externally stiffened ring connections between concrete-filled steel tubular columns and reinforced concrete beams

Abstract Concrete-filled steel tubular (CFST) columns are widely used in high-rise and long-span structures due to their high strength, stiffness, and ductility. However, conventional CFST column–reinforced concrete (RC) beam connections usually involve complex detailing, column...

Interpretable machine learning for identifying mild cognitive impairment among Chinese patients with obstructive sleep apnea: a multicenter cross-sectional study

Mild cognitive impairment (MCI) is clinically relevant in obstructive sleep apnea (OSA). We developed and externally validated an interpretable machine-learning model for concurrent clinically defined MCI to support prioritization for formal cognitive assessment rather than diagn...

Defective PDZK1 palmitoylation impairs epididymosome-mediated cholesterol transport and contributes to asthenozoospermia

Asthenozoospermia, a leading cause of male infertility characterized by impaired sperm motility, involves dysregulated cholesterol efflux during epididymal maturation, yet the underlying mechanisms remain elusive. Here, we demonstrate that PDZK1 protein level and its palmitoylati...

Short-term neonatal in-hospital associations following delivery room ETI versus PPV resuscitation: a multicenter retrospective cohort study

Abstract Background Endotracheal intubation (ETI) and positive pressure ventilation (PPV) are core neonatal resuscitation interventions. Baseline clinical imbalances confound gestational-age (GA)-specific associations between ETI and in-hospital adverse events. We evaluated GA-st...

circBIRC6 regulates cisplatin resistance of choroidal melanoma via positively modulating ERK by sponging miR-503-3p

Abstract Background/AimscircRNA plays a key regulatory role in various human tumors. This study was carried out to investigate the molecular mechanism of circBIRC6 in the regulation of choroidal melanoma cisplatin (DDP) resistance. MethodsThe expression of circBIRC6 in choroidal...

Global research landscape of natural medicines for lower urinary tract symptoms: bibliometric and clinical trial analysis

Abstract Background Natural medicines have demonstrated significant therapeutic potential in the management and attenuation of lower urinary tract symptoms (LUTS). According to the Web of Science Core Collection (WoSCC), a total of 497 related articles have been published during...

The bile acid receptor TGR5 promotes functional recovery after spinal cord injury by rescuing mitochondrial dysfunction and suppressing AIM2‐mediated pyroptosis

Background and Purpose Previous studies have highlighted the significance of the bile acid receptor TGR5 (also known as Takeda G protein‐coupled receptor 5) in regulating inflammation and mitochondrial homeostasis in various diseases, whereas the specific involvement of TGR5 in s...