Shenzhen Institute of Synthetic Biology

An automated operon refactoring workflow for heterologous expression of non-ribosomal peptide biosynthetic gene clusters

Microbial genomes encode numerous biosynthetic gene clusters, yet most remain experimentally uncharacterized, particularly large non-ribosomal peptide synthetase (NRPS) clusters that resist conventional cloning. Existing refactoring approaches are labor-intensive, depend on de no...

Revolutionizing drought defense: The water-plant-microbe synergy in climate-smart agriculture

Global warming-induced water scarcity threatens agricultural sustainability. While precision irrigation and microbial inoculants are recognized as effective individual strategies, their synergistic potential remains under-explored. This review synthesizes recent advances in the "...