Shenzhen Institute of Information Technology

CoxFormer enables spatial omics inference with multimodal generative modeling

Gene co-expression maps transcriptome-wide gene-gene relationships, yet high-quality estimates cover less than half the genome. Meanwhile, spatial omics either profiles restricted in situ panels or lacks cellular resolution. Extending co-expression transcriptome-wide could overco...

From chemical oscillators to biological synchrony: a programmable reaction-diffusion model for studying signal coordination in cardiomyocyte networks

Abstract The self-organization of asynchronous rhythms into synchronized beating in in vitro cardiomyocyte networks is a fundamental problem in systems biology research. Inspired by the dynamics of chemical oscillators, this paper presents a programmable model framework based on...

Integrating macrophage biology and bioengineering for vascularization in regenerative medicine

Macrophages play central roles in vascularization during tissue regeneration through their dynamic immunomodulatory and angiogenic functions. This review summarizes strategies to regulate vascularization by directly delivering macrophages, cytokines, or extracellular vesicles, an...

High frequency of urban new particle formation on the Tibetan Plateau: quantifying formation rates, growth rates, and CCN production

Abstract. New particle formation (NPF) strongly influences aerosol number size distributions and cloud condensation nuclei (CCN), yet its characteristics and climatic relevance in high-altitude urban environments over the Tibetan Plateau (TP) remain poorly constrained. We conduct...

Comparison of Nonlinear Dynamics for Rotor Supported by Aerostatic Journal Bearings with Small-Hole and Micro-Hole Restrictors

Aerostatic journal bearings with small-hole restrictors are widely adopted due to their superior stiffness, making them effective solutions to meet the growing demands for improved stability and higher rotational speeds in precision machinery. In this study, the nonlinear dynamic...

Validation Study on Fault Diagnosis of Elevator Traction Drive Systems Based on Public Motor-Drive Data and Multimodal Signal Analysis

To address the difficulty of obtaining real fault data from elevator traction drive systems and the potential overestimation caused by random window splitting, this study uses two public motor-drive datasets to examine how validation protocols, signal modalities, and noise condit...

Predicting infection risk in rheumatoid arthritis patients receiving biological or targeted synthetic disease-modifying anti-rheumatic drugs: an application of machine learning and healthcare big data

Patients with rheumatoid arthritis (RA) initiating biologic or targeted synthetic disease-modifying antirheumatic drugs (b/ts DMARDs) face elevated risk of serious infections, necessitating tools for individualized risk stratification. Primary objective was to develop and validat...

Plant‐Derived Extracellular Vesicle‐Like Nanoparticles and Decoction Nanoparticles Exhibit Distinct Therapeutic Effects in Alcoholic Liver Disease via Gut Homeostasis and Macrophage Regulation

Nanoparticles originating from plants have attracted increasing attention owing to the excellent biocompatibility and high potential in disease prevention. Various types of plant-derived nanoparticles have been extensively studied; however, comparative investigations of different...

Extracting structure–activity relationships from patents with large language models

Abstract Background Persistent clinical failures in drug development arise from multiple factors, including imbalanced molecular properties, underscoring the need for systematic structure–activity relationship analysis to link structural modifications with optimized efficacy, sel...