Shenzhen Children's Hospital

Weight-stratified analysis of the heterogeneous effects of miniaturized cardiopulmonary bypass on perioperative outcomes in children with congenital heart disease: A retrospective cohort study

Introduction Miniaturized cardiopulmonary bypass (CPB) circuits may reduce intraoperative transfusion in pediatric cardiac surgery, but their effects across body weight categories remain unclear. This study compared transfusion and outcomes between conventional and miniaturized C...

Plasma interleukin-1 receptor antagonist in pediatric patients as a potential biomarker for sepsis-associated acute kidney injury: a cohort study

Our goal is to evaluate the potential of interleukin-1 receptor antagonist (IL-1Ra) as a biomarker for sepsis-associated acute kidney injury (SA-AKI). Specifically, we aim to explore the correlation between acutely elevated endogenous IL-1Ra and SA-AKI, and to identify the potent...

Multidisciplinary management of congenital portosystemic shunt complicated by multifocal hepatoblastoma: a case report

Congenital portosystemic shunt (CPSS) is a rare developmental malformation that predisposes individuals to an increased risk of hepatic tumors. Hepatoblastoma (HB) complicating CPSS is especially rare. This article reports a 2‑year‑old male with CPSS (Park type I) and HB (PRETEXT...

Head-up lateral positioning during emergence from anaesthesia after ambulatory adenotonsillectomy in children: protocol for a multicentre randomised controlled trial

Tonsillectomy and adenoidectomy are common paediatric surgeries, with > 50% of children experiencing postoperative respiratory adverse events (PRAEs). Existing mitigation strategies have limitations, and evidence on positional interventions (e.g. lateral/semi-reclined) specifical...

Application of palliative tunneled patient-controlled epidural analgesia in children with refractory cancer-related visceral pain and breakthrough pain: case report

Managing refractory cancer-related pain in pediatric patients with terminal-stage malignancies presents significant challenges, particularly when complicated by intestinal obstruction and cachexia. Conventional systemic analgesics often prove inadequate or intolerable. A 10-year-...

A phase II trial of chemotherapy-free neoadjuvant camrelizumab plus apatinib for resectable HNSCC: pathological response and vascular-immune crosstalk

Abstract Purpose: To evaluate the efficacy, safety, and tumour microenvironment remodelling of neoadjuvant camrelizumab plus apatinib in resectable head and neck squamous cell carcinoma (HNSCC; stage II–IVA). Materials and Methods: In this single-arm, exploratory phase II trial (...

Autophagy-regulating bioactive nanoparticle alleviates MASH via gut–liver axis-mediated mitochondria/cAMP/GLP1 pathway

Chronic exposure of the liver to diverse insults can lead to metabolic dysfunction-associated steatohepatitis (MASH), a complex metabolic disorder characterized by hepatic steatosis and inflammation, often accompanied by progressive fibrosis, intestinal barrier dysfunction, and i...

Preliminary experience of mechanical thrombectomy treatment in pediatric arterial ischemic stroke: a retrospective case series

To evaluate the feasibility and efficacy of mechanical thrombectomy in the treatment of pediatric acute ischemic stroke (AIS). The clinical data, radiographic results and management outcomes of children diagnosed with AIS and treated at our hospital between 2016 and 2021 were ret...

Comprehensive genomic characterization of extraintestinal pathogenic Escherichia coli isolated from neonates: multiple center insights into virulence, resistance, and transmission dynamics

Neonatal extraintestinal pathogenic Escherichia coli (ExPEC), which can cause severe long-term sequelae by systemic infections, is gradually becoming the primary pathogen threatening neonatal health. The lack of large-scale genomic epidemiological investigation hinders further un...

Glymphatic-meningeal lymphatic dysfunction drives remote organ injury after aneurysmal subarachnoid hemorrhage: a unified neuroimmune framework and time-stratified therapeutic roadmap

Aneurysmal subarachnoid hemorrhage (aSAH) confers substantial mortality and morbidity driven not only by primary brain injury but also by systemic remote organ complications across the pulmonary, cardiac, renal and gastrointestinal systems. Despite growing recognition of neuroimm...