Shenyang Medical College

LncRNA RBMS3-AS3 promotes ovarian cancer progression by regulating QKI and RBFOX2

Long non-coding RNAs (lncRNAs) exert pivotal regulatory functions in the malignant progression of ovarian cancer. Despite this, the biological roles and underlying molecular mechanisms of lncRNA RBMS3-AS3 in ovarian cancer pathogenesis have yet to be fully elucidated. RBMS3-AS3 i...

CYP2S1: a novel regulator of PMN-MDSC recruitment and immunotherapy resistance in esophageal squamous cell carcinoma

Chemoimmunotherapy resistance significantly limits the clinical management of esophageal squamous cell carcinoma (ESCC). To identify tumor-intrinsic regulators associated with an immunosuppressive tumor microenvironment (TME) and treatment failure, we integrated proteomic profili...

The potential effects, mechanisms and translational perspectives of natural products in the treatment of atopic dermatitis

Abstract Background Atopic dermatitis (AD) is a common chronic inflammatory skin disorder with a continuously increasing global incidence. Current therapeutic options are often associated with adverse effects. In recent years, natural products have attracted considerable attentio...

Systematic review and meta-analysis of intermittent theta burst stimulation therapy for improving cognitive function in the elderly population

Intermittent theta-burst stimulation (iTBS) is an effective neuromodulation approach for major depressive disorder (MDD). With population aging, age-related cognitive decline has become an increasingly heavy social burden. However, the intervention effect of iTBS on cognitive fun...

Latent classes and determinants of depressive and anxiety symptoms among older adults with chronic diseases in rural China

The mental health of older adults with chronic diseases in rural, underdeveloped regions of China poses a critical public health challenge. Comorbid depressive and anxiety symptoms are highly prevalent but exhibit substantial heterogeneity, necessitating person-centered approache...

Intrinsic capacity decline and multilevel intervention needs of disabled older adults in nursing homes: a qualitative study based on the social-ecological systems theory

Intrinsic capacity (IC) is a central pillar of healthy ageing. Diminished IC is closely associated with poorer health outcomes and a greater degree of care dependence among disabled older adults. This study used the social-ecological framework to examine lived experiences and int...

Hyperbaric oxygen therapy modulates immune aging in a personalized manner: a linear mixed-effects analysis

Abstract Background Immunosenescence, characterized by telomere shortening, senescence-associated T-cell subsets, and chronic inflammation, is a hallmark of biological aging. Whether these aging-related immune biomarkers can be modulated through short-term intervention and whethe...