Shenyang 242 Hospital

Gut microbiome features in methamphetamine use disorder: external validation of a candidate marker panel and exploratory multi-omics associations

Abstract Methamphetamine use disorder (MUD) is a chronic, relapsing disorder with symptoms most pronounced during withdrawal, yet objective biomarkers remain lacking. Although gut microbial alterations have been reported in substance use disorders, their potential as candidate ma...

Exploring the association between gastroesophageal reflux disease and hyperlipidemia through bioinformatics and Mendelian randomization

Observational research has found a relationship between gastroesophageal reflux disease (GERD) and hyperlipidemia (HLP). This study explored the relationship between GERD and HLP using bioinformatics and Mendelian randomization (MR) methods. We first conducted bioinformatics anal...

Association of prenatal exposure to PM2.5 and its chemical constituents with early childhood obesity: A population-based study

A growing body of evidence links gestational fine particulate matter (PM 2.5 ) exposure to elevated childhood obesity risk, yet research on the combined impacts and respective contributions of different PM 2.5 chemical constituents remains limited. This large population-based pro...

Dual Regulation of ACSL3 by TRIM33-Mediated Ubiquitination and NBR1-Dependent Autophagy: A Therapeutic Target for Cerebral Ischemia-Reperfusion Injury

Background: Cerebral ischemia-reperfusion injury (CIRI) is a key contributor to stroke-related neurological damage, but the functional interplay between autophagy and ferroptosis—two critical pathological processes—remains poorly understood. Methods: Using oxygen-glucose deprivat...