Sheffield Teaching Hospitals NHS Foundation Trust

The association between collagenopathies and the risk of spontaneous preterm birth: A systematic review with selective meta‐analysis

INTRODUCTION: Spontaneous preterm birth (sPTB) remains a leading cause of neonatal morbidity and mortality. Inherited collagenopathies, including Ehlers-Danlos syndrome (EDS) and Marfan syndrome (MFS), may predispose to sPTB through impaired connective tissue integrity; however,...

Diabetic Peripheral Neuropathy: Implementing Guidelines into Practice

Diabetic Peripheral Neuropathy (DPN) is a common and debilitating complication of diabetes, affecting up to 50% of patients. Early identification and management of DPN are crucial to minimize complications and maintain patient quality of life. Multiple guidelines have been develo...

Mapping the Evidence for Allied Health Interventions for Preterm Infants With Feeding Aversion: A Scoping Review

AIMS: To identify and map the evidence on allied health professional led interventions for preterm infants with feeding aversion, and to critically examine the literature to inform clinical practice and highlight research gaps. METHODS: A Joanna Briggs Institute scoping review wa...

Treat (the whole of) me: a systematic review and qualitative meta-ethnographic synthesis of the experiences of women with POP, SUI or mesh complications in the context of surgical treatment

Abstract Background Stress Urinary Incontinence (SUI) and Pelvic Organ Prolapse (POP) are common pelvic floor disorders that may significantly impact women’s quality of life. Surgical interventions are available to treat these conditions, some using synthetic mesh. Whilst most wo...

How to manage: acute-on-chronic liver failure

Acute on chronic liver failure has emerged as a distinct clinical entity over the past few decades. While mortality remains highest for patients who develop liver and multiple non-liver organ failures, earlier recognition of the syndrome, including identification and management o...

Thalamic neuronal and bioenergetic function in painful diabetic peripheral neuropathy: a dual magnetic resonance spectroscopy study

Abstract Aims/hypothesis The aim of this cross-sectional study was to investigate three imaging parameters in people with type 2 diabetes to examine the volume, neuronal function and bioenergetic status of the thalamus in painful diabetic peripheral neuropathy (DPN) compared with...

Pain alleviation in diabetic neuropathy using hybrid closed loop insulin pumps (PAINLESS) – A randomised crossover trial protocol

Introduction Painful diabetic neuropathy (PDN) is a common complication of diabetes that leads to significant co-morbidity. Emerging evidence suggests glycaemic variability may be linked to fluctuations in pain intensity. Hybrid closed loop (HCL) systems reduce glycaemic variabil...

Towards a deep-learning genomic tool for risk stratification and diagnostic support in sporadic ALS

Abstract Background A variety of common and rare genetic factors have been implicated in the development of amyotrophic lateral sclerosis (ALS), and the evidence is that a genetic component is present in most affected individuals. However, our current understanding of ALS genetic...

Dysphagia care processes on acute stroke wards: an ethnographic study of barriers and facilitators relevant to stroke‐associated pneumonia

Introduction Dysphagia is associated with increased risk of stroke-associated pneumonia (SAP). The multifactorial pathophysiology of SAP and the interplay of care processes make it challenging to unpack which components are associated with risk of SAP. The aim of the research was...

Integrating evidence-based medicine into UK general surgical training: a modified Delphi consensus study

Abstract Background Recent research has highlighted inconsistent teaching and application of Evidence-Based Medicine (EBM) within General Surgery. Existing international EBM competency frameworks are not tailored to the specific requirements of surgical training, and no specialty...

Remote STrOke Rehabilitation (ReSTORe): study protocol for a randomised controlled trial

Abstract Background At least one third of long-term stroke survivors living at home experience ongoing (≥6 months) mild to moderate disability including fatigue, low functional capacity, muscle weakness, anxiety, and depression. Health-related quality of life (HRQoL) and societal...

Barriers to the uptake of cervical cancer screening methods in Low- and Middle-Income Countries (LMICs) – a scoping review using framework thematic analysis

Abstract Background Cervical cancer remains a major cause of preventable death among women in low- and middle-income countries (LMICs). Despite the availability of effective screening, uptake remains low. Existing reviews have not fully captured the socio-cultural and behavioural...

Keeping people with dementia moving in hospital to reduce pressure ulcer risk: complexities in care

People with dementia occupy up to 21% of UK hospital beds at any one time and are at increased risk of developing pressure ulcers. Keeping moving is a fundamental component of pressure ulcer prevention. However, the physical, behavioural and psychological symptoms of dementia can...