Shaoxing People's Hospital

Lanthanide phosphors doped stimuli‐responsive fibres for advanced information encryption and anti‐counterfeiting: In both dark and bright situation

Abstract The increasing prevalence of flexible wearables underscores the urgent need for advanced anti‐counterfeiting technologies. However, photoluminescent anti‐counterfeiting fibre materials are currently plagued by inherent environmental light dependency flaws. Their fluoresc...

Possible sarcopenia defined by the 2025 Asian Working Group for sarcopenia consensus and functional impairment among adults aged 50–64 years: a longitudinal cohort study

Background The Asian Working Group for Sarcopenia (AWGS) 2025 consensus simplified possible sarcopenia assessment and extended it to adults aged 50–64 years, but its association with activities of daily living (ADL)/instrumental activities of daily living (IADL) impairment in thi...

A novel composite residual viable tumor score redefines prognosis in oral squamous cell carcinoma following neoadjuvant immunochemotherapy

Standard ypTNM staging may not capture residual viable tumor (RVT) across primary and nodal sites after neoadjuvant immunochemotherapy (NICT) for locally advanced oral squamous cell carcinoma (OSCC). Our aim was to derive and internally evaluate a composite RVT score. This retros...

3D‐Printed Dual‐Gradient Gel Electrodes Synchronize Ion Transport and Active‐Site Utilization for High‐Energy Zinc‐Ion Hybrid Supercapacitors

ABSTRACT High‐mass‐loading gel electrodes are critical for practical zinc‐ion hybrid supercapacitors, but sluggish ion penetration and depth‐dependent reaction heterogeneity hinder their performance. Herein, we report a dual‐gradient MXene/polypyrrole@Carbon nanotube gel composit...

Polyendocrine metabolic ovarian syndrome (PMOS, formerly Polycystic Ovary Syndrome): a systems-biology perspective on neuroendocrine, immuno-metabolic and epigenetic mechanisms across the life course

Polyendocrine metabolic ovarian syndrome (PMOS) is the name adopted in 2026 by the Global Name Change Consortium for the condition previously called polycystic ovary syndrome (PCOS); diagnostic criteria are unchanged, and a managed three-year transition to the new terminology is...

Effectiveness and Safety of Fixed‐Dose Combination Metformin and Empagliflozin in Type 2 Diabetes: A Prospective, Multicenter, Real‐World Study From China

BACKGROUND: This study assessed the real-world effectiveness and safety of a fixed-dose combination (FDC) of metformin and empagliflozin in Chinese patients with type 2 diabetes mellitus (T2DM). METHODS: This prospective, multicenter, real-world study enrolled consecutive patient...

Targeting SIRT2-mediated mitophagy to enhance ferroptosis: a novel mechanism of berberine action in non-small cell lung cancer

INTRODUCTION: Berberine (BBR), a natural isoquinoline alkaloid, has been shown to specifically bind to sirtuin 2 (SIRT2) and exhibit anticancer activity. This study aimed to elucidate the therapeutic mechanisms of BBR in non-small cell lung cancer (NSCLC). MATERIAL AND METHODS: A...

Evaluation of bone fracture risk among men with prostate cancer treated with androgen receptor pathway inhibitor-containing therapies: a systematic review and meta-analysis

Androgen receptor pathway inhibitors (ARPIs) are widely used across multiple prostate cancer disease states, but fracture outcomes are inconsistently reported across randomized trials. We aimed to quantify the risks of all-grade and grade ≥ 3 trial-reported fracture-related adver...

The imaging features of neurovascular compression in hemifacial spasm patients

Neurovascular compression is considered the main cause of primary hemifacial spasm. However, it also occurs on the asymptomatic facial nerves in primary hemifacial spasm patients and in healthy controls. This study aimed to compare neurovascular compression features among the thr...

An expert-level generalist AI for abdominal CT diagnosis

Artificial intelligence (AI) in radiology aspires to deliver expert-level diagnosis across diverse clinical tasks, yet existing supervised strategies remain limited in scope. We developed RADAR, a generalist vision-language model trained on more than 400,000 contrast-enhanced abd...

High TG/low HDL-C ratio–mimetic lipid stress drives diabetic atherosclerotic endothelial–macrophage dysfunction through glycocalyx disruption and CD36/ABCA1 imbalance

A high triglyceride/high-density lipoprotein cholesterol (TG/HDL-C) ratio is strongly associated with insulin resistance and atherosclerotic cardiovascular risk, but the cellular mechanisms linking this lipid imbalance to vascular injury remain incompletely defined. This study es...

The role of lipid metabolism in immune thrombocytopenia: new perspectives from immune inflammation and thrombopoiesis

Abstract Background Primary immune thrombocytopenia (ITP) is an autoimmune condition defined by increased immune-driven platelet destruction and inadequate platelet generation. Emerging research highlights that global alterations in lipid metabolism are closely associated with im...

UGGT1 mediates N-glycosylation of LGALS3BP to induce angiogenesis in liver cancer via the NOTCH signaling pathway

Abstract Background Liver cancer (LC) is one of the leading causes of cancer-related deaths worldwide. Its complex vascular regulatory network and drug resistance severely limit clinical efficacy. Although LGALS3BP is highly expressed in various malignant tumors, its biological f...

Brain calcification‐associated JAM2 pathogenic mutations impair JAM2 – JAM3 tight junction structure and the blood–brain barrier integrity

Abstract Primary brain calcification (PBC) is a neurodegenerative disorder characterized by bilateral brain calcification. JAM2 is a PBC causative gene, encoding the tight junction protein JAM2 and critical for blood–brain barrier (BBB) integrity, with an uncertain pathogenic mec...

Chemical Mediation Mechanism Decouples Solid State Kinetics for High‐Power Aqueous Zn‐Co Batteries

ABSTRACT Solid state conversion electrodes are promising for aqueous energy storage but are frequently constrained by sluggish interfacial kinetics, leading to a persistent energy‐power trade‐off and underutilized capacity at high rates. Here we propose a chemical mediation strat...

A multimodal Vision-Mamba model based on non-contrast CT hematoma and shell features predicts early hematoma expansion in hypertensive intracerebral hemorrhage: a multicenter study

To develop and evaluate a multimodal Vision-Mamba deep learning (DL) model integrating clinical data, noncontrast computed tomography (NCCT) hematoma features, and shell features to predict early hematoma expansion (EHE) in hypertensive intracerebral hemorrhage (HICH). In this mu...

Ki-67/p53-associated angiogenic heterogeneity for preoperative WHO grading of meningiomas: a spatial habitat radiomics study

This study aimed to develop and validate a classification model for preoperative prediction of WHO grading of meningioma based on spatial habitat radiomics that can be explained by Ki-67 and p53 biomarkers. A retrospective cohort of 400 patients (261 WHO grade I; 139 grade II/III...