Shanxi Provincial Cancer Hospital

Extracellular Vesicles: Emerging Players in Tumor Progression, Diagnosis, and Therapeutic Applications

Abstract Extracellular vesicles (EVs) are emerging as critical players in oncology and also exert vital regulatory effects on exercise-induced muscle injury repair, offering novel insights into tumor biology. Tumor-derived EVs facilitate intercellular communication by carrying bi...

Transillumination improves lymph node yield in left-sided colorectal cancer: an ambispective cohort study

Accurate lymph node (LN) staging is essential for prognosis and treatment decisions in colorectal cancer (CRC). Existing methods to assist LN retrieval, such as fat-clearing and methylene blue staining, improve yield but are complex, time-consuming, and require additional reagent...

Effect of TC chemotherapy + Beva + Tislelizumab in patients with recurrent cervical cancer and its influence on survival

To evaluate the efficacy and survival outcomes of TC chemotherapy combined with bevacizumab and tislelizumab in patients with recurrent cervical cancer. A total of 50 patients with recurrent cervical cancer treated between May 2019 and May 2023 were retrospectively analyzed. Pati...

Polydopamine-assisted architecture-enabled local delivery of miR-34a-loaded M1 macrophage extracellular vesicles and curcumin from an injectable thermogelling hydrogel for triple-negative breast cancer

Triple-negative breast cancer (TNBC) remains difficult to treat because of its aggressive phenotype, limited targetable pathways, and the need for local delivery systems that improve therapeutic retention without compromising cargo integrity. In this study, we engineered an injec...

Deep learning predicts gene rearrangements from histopathology in large B-cell lymphoma

Abstract Large B-cell lymphomas are molecularly heterogeneous mature B-cell neoplasms in which assessment of MYC , BCL2 , and BCL6 rearrangement status contributes to integrated diagnosis, risk stratification, and treatment planning. Fluorescence in situ hybridization (FISH) rema...

Death anxiety and its associated factors among palliative care nurses in China: a multicenter cross-sectional study

To investigate the current status of death anxiety among palliative care nurses, explore its associated factors based on the Conservation of Resources theory, and provide an empirical reference to inform future targeted clinical interventions. A multicenter cross-sectional study...

Neoadjuvant Anbenitamab and HB1801 in ERBB2 -Positive Breast Cancer

IMPORTANCE The combination of neoadjuvant taxanes with trastuzumab and pertuzumab remains the cornerstone treatment strategy in ERBB2 -positive breast cancer. Anbenitamab (a ERBB2 -biparatopic antibody that induces profound receptor clustering) and HB1801 (a solvent-free albumin-...

Discordant mismatch repair status between colon and rectal adenocarcinomas in a single patient: a case report

Colorectal cancer (CRC) is the most common malignant tumor of the digestive tract, with steadily increasing annual incidence and mortality rates. Mismatch repair (MMR) status and microsatellite instability (MSI) are critical biomarkers for the diagnosis and management of CRC. MSI...

The genetic association between celiac disease and risk of functional dyspepsia

Celiac disease (CeD) is a common autoimmune disease of the small intestine triggered by ingesting gluten-containing foods. Chronic symptoms are characteristic of functional dyspepsia (FD), including chronic epigastric pain and burning. The clinical and genetic overlap between FD...

From synthesis to clinic: a task-specific framework for CT images metal artifact reduction in cervical brachytherapy

Severe metal artifacts in cervical brachytherapy CT scans obscure critical anatomical structures and applicator geometry. Existing metal artifact reduction (MAR) models are inadequate in addressing these complex artifacts, leading to uncertainties in organs at risk (OARs) delinea...