Shanxi Cardiovascular Hospital

AI-assisted telerehabilitation in early Parkinson’s disease: a multicenter, randomized, multi-arm comparative trial

Abstract This exploratory, multicenter, randomized, rater-blinded, multi-arm comparative trial aimed to evaluate the feasibility and exploratory clinical signals of an AI-facilitated telerehabilitation system across different intervention durations in early-stage Parkinson’s dise...

Effects of laparoscopic radiofrequency ablation combined with a levonorgestrel-releasing intrauterine system in patients with adenomyosis

To compare the 12-month clinical outcomes of laparoscopic RFA alone with those of laparoscopic RFA combined with LNG-IUS in patients with symptomatic adenomyosis. This single-center retrospective cohort study included 70 patients with adenomyosis who had complete 12-month follow-...

Development of a recurrence risk prediction model for intracranial atherosclerotic stroke using HR-VWI combined with radiomics

Based on high-resolution vessel wall imaging (HR-VWI) and radiomics, this study constructed a predictive model for stroke recurrence in patients with symptomatic intracranial atherosclerotic stenosis (sICAS), and evaluated the performance of the model. This study retrospectively...

Unravelling gut-kidney axis alterations in BPA-related CKD: Integrating network toxicology and machine learning with experimental validation

Background Chronic kidney disease (CKD) has a complex pathogenesis. Exposure to bisphenol A (BPA) is closely associated with its occurrence and development. Although it is known that BPA can affect the gut microbial community and that the gut-kidney axis serves a crucial role in...

Association between cardiometabolic index and lung function in US adolescents

Obesity is a key determinant of pulmonary function. The cardiometabolic index (CMI), which integrates body fat distribution and lipid metabolism status, directly reflects cardiovascular metabolic risk and health status. However, previous studies have not explored its relationship...

A segmentation-guided CNN–Vision transformer feature fusion framework for multi-class breast ultrasound image classification

Breast ultrasound (BU) imaging is widely used for detecting breast abnormalities because it is cost-effective, non-invasive, and suitable for dense breast tissue. However, multi-class classification of BU images is considered a challenging task due to low contrast, speckle noise,...

Quality, guideline concordance, and dangerous misinformation in pediatric febrile seizure videos on Chinese short-video platforms: a cross-sectional study

Abstract Background Febrile seizures affect 2–5% of children under 5 years and, although clinically benign, are among the most frightening events a caregiver can witness. Parents increasingly seek first-aid information on Chinese short-video platforms, where content is surfaced b...

A dual GLP-1/GIP agonist inhibits oxidative stress in diabetic rats with cerebral ischemia-reperfusion injury by activating the Nrf2/ARE signaling pathway

Stroke is the leading cause of disability-affected life years in China, posing a great social hazard. Diabetes is a chronic disease that seriously affects human health that can aggravate cerebral ischemia - reperfusion injury. Oxidative stress is the main mechanism through which...

Stress hyperglycemia ratio as a risk factor for delirium in older intensive care unit patients: a retrospective cohort study

Delirium is a severe neurocognitive complication in older ICU patients, associated with poor outcomes. The stress hyperglycemia ratio (SHR), reflecting acute hyperglycemia relative to chronic glycemic control, may predict adverse outcomes. This study examined the association betw...

Can digital gait biomarkers complement the WHO intrinsic capacity framework in fall risk stratification? A cross-sectional exploratory analysis

The World Health Organization (WHO) Intrinsic Capacity (IC) framework serves as a holistic construct for healthy aging and fall risk screening. However, current IC assessments predominantly rely on subjective reports or macroscopic physical tests, which may lack the sensitivity t...

Effectiveness of digital health interventions for the management of Low Anterior Resection Syndrome (LARS) after sphincter-preserving surgery for rectal cancer: a systematic review and meta-analysis

Low anterior resection syndrome (LARS) frequently occurs following sphincter-preserving rectal cancer surgery. Although recent studies have reported the effects of digital health interventions for LARS management, no systematic review and meta-analysis has been conducted. We sear...

Hypoxia combined with vitamin C and N-acetylcysteine attenuates telomere shortening and replicative senescence in human umbilical cord mesenchymal stem cells

Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) are promising candidates for regenerative medicine; however, prolonged in vitro expansion promotes oxidative stress, replicative senescence, functional deterioration, and telomere attrition. This study evaluated wheth...

The genetic association between celiac disease and risk of functional dyspepsia

Celiac disease (CeD) is a common autoimmune disease of the small intestine triggered by ingesting gluten-containing foods. Chronic symptoms are characteristic of functional dyspepsia (FD), including chronic epigastric pain and burning. The clinical and genetic overlap between FD...

Effects of acupuncture on brain function in patients with depression

Background: Depression poses a major global health burden. Many patients exhibit treatment resistance or experience intolerable side effects with standard therapies. Acupuncture shows promise as an adjunctive therapy for depression, but its neurobiological mechanisms remain incom...

Toward therapnostic integration as a new paradigm for precision management of interstitial cystitis driven by medical-engineering convergence

Abstract Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS) is a complex chronic inflammatory disease involving mucosal barrier defects, neurogenic inflammation, mast cell activation, and tissue remodeling. Current diagnosis lacks objective biomarkers, relying instead on sympto...