Shanxi Academy of Medical Sciences

ZMIZ1 promotes aerobic glycolysis and development of hepatocellular carcinoma through inducing NOTCH1-mediated transcription of PYCR1

Hepatocellular carcinoma (HCC) is characterized by profound metabolic reprogramming that promotes tumor progression. Although zinc finger MIZ-type containing 1 (ZMIZ1) has been implicated in several malignancies, its biological function and underlying mechanism in HCC remain uncl...

Effects of acupuncture on brain function in patients with depression

Background: Depression poses a major global health burden. Many patients exhibit treatment resistance or experience intolerable side effects with standard therapies. Acupuncture shows promise as an adjunctive therapy for depression, but its neurobiological mechanisms remain incom...

Fertility-related distress and female identity reconstruction among reproductive-age women with breast cancer in China: a qualitative study

Breast cancer is increasingly diagnosed among Chinese women of childbearing age. Cancer treatments carry variable gonadotoxic risks that participants feared could lead to lasting reproductive impairment, triggering widespread fertility-related distress closely intertwined with fe...

From synthesis to clinic: a task-specific framework for CT images metal artifact reduction in cervical brachytherapy

Severe metal artifacts in cervical brachytherapy CT scans obscure critical anatomical structures and applicator geometry. Existing metal artifact reduction (MAR) models are inadequate in addressing these complex artifacts, leading to uncertainties in organs at risk (OARs) delinea...

Novel Autoantibodies in Rheumatoid Arthritis: Translational Prospects from Seronegative Breakthrough to Precision Diagnosis and Treatment

Rheumatoid Arthritis (RA) is an autoimmune disease characterized by chronic, erosive synovitis. While significant progress and breakthroughs have been made in disease diagnosis through basic research and clinical practice, approximately 30%–40% of seronegative RA patients still e...

Transcriptomic and Metabolomic Analysis Following LmRab11A Knockdown Reveals Its Role in Metabolic Regulation and Molting in Locusta migratoria

Rab proteins are key members of the Ras superfamily that regulate vesicular trafficking in eukaryotic cells, ensuring accurate cargo transport and cellular homeostasis. To investigate the functional role of Rab proteins, RNA interference (RNAi) was employed to silence LmRab11A in...

Cancer drug response and resistance: molecular mechanisms and combating strategies

Despite remarkable advances in cancer drug treatment, including chemotherapy, targeted therapy, and immunotherapy, therapeutic resistance remains a formidable clinical barrier, limiting durable responses and long-term survival. Drug resistance can be broadly categorized as intrin...

Probiotic-hydrogel systems for microbiome-associated diseases: design principles, preclinical evidence, and translational challenges

The human microbiome provides a robust ecosystem for mucosal barrier function, immune regulation, metabolism, and resistance to pathogen infection. Dysbiosis causes inflammatory bowel disease, oral inflammation, wound damage, skin disease, and cancer-related immune dysregulation....