Shantou University Medical College

BurnAreaNet: a deep learning method for total body surface area estimation from 2D masks

Accurate estimation of total body surface area (TBSA) is critical for burn diagnosis, triage, and prognosis. It represents the burned area as a proportion of the total body surface area, and is usually expressed as a percentage value. Traditional methods are subjective, while exi...

Linking centromere stretch to SAC signaling in mammalian oocytes with insights from modified kinetochore model

Abstract The spindle assembly checkpoint (SAC) monitors kinetochore-microtubule interactions to ensure accurate chromosome segregation. In mitosis, investigation of its silencing at anaphase centers on whether attachment or tension is the key signal, while in meiosis for mammalia...

Analysis of immediate upstream gene regions in orthopoxvirus genomes through the use of DNA Duplex Stability and explainable machine learning

Orthopoxviruses are double-stranded DNA viruses with a temporally regulated gene expression program divided into early, intermediate, and late stages. Although many temporal gene functions are known, the promoter features that distinguish expression program require more precise c...

Knowledge and attitudes about artificial intelligence and its applications among Chinese endodontic practitioners: a cross - sectional survey

Artificial intelligence (AI) has been increasingly applied in dentistry, including cariology and endodontics. However, evidence remains limited regarding endodontic practitioners’ AI literacy, perceptions, clinical usage, and barriers to AI integration. This study aimed to invest...

Self-assembled products from natural active compounds: mechanisms and applications in cancer therapy

Natural active compounds (NACs) possess diverse anticancer activities but are often limited by poor aqueous solubility, low bioavailability, insufficient tumor selectivity, and inadequate in vivo stability. Self-assembled products from natural active compounds (SAPNACs) provide a...

Influencing factors and the pathway analysis of demoralization among stroke patients: a cross-sectional study

Demoralization was found to seriously harm patients‘ disease outcomes and quality of life, and could even lead to suicidal ideation and shorten life expectancy. Understanding the level of demoralization in stroke patients and exploring its mechanism wasconsidered not only conduci...

Multidisciplinary management of congenital portosystemic shunt complicated by multifocal hepatoblastoma: a case report

Congenital portosystemic shunt (CPSS) is a rare developmental malformation that predisposes individuals to an increased risk of hepatic tumors. Hepatoblastoma (HB) complicating CPSS is especially rare. This article reports a 2‑year‑old male with CPSS (Park type I) and HB (PRETEXT...

Large-scale esophageal cancer screening through noncontrast computed tomography and artificial intelligence

The absence of accurate, noninvasive, scalable screening tools keeps early esophageal cancer (EC) detection a global health challenge. Although noncontrast computed tomography (NC CT) is widely accessible, the esophagus is a hollow tubular structure prone to collapse and motion a...

Beyond Vaccine Coverage: The Neglected Treatment-Readiness Gap in Diphtheria Outbreak Response

Diphtheria has re‑emerged across the WHO African Region, with more than 20,000 suspected cases and over 1,200 deaths reported in 2025 alone. The conventional explanation centres on vaccine‑coverage gaps among zero‑dose and under‑immunized children. This narrative review argues th...

A clinico-radiomic nomogram for preoperative prediction of guideline-defined indications for postoperative adjuvant therapy in early-stage cervical cancer

To develop and validate an integrated clinico-radiomic nomogram for the preoperative prediction of guideline-defined indications for postoperative adjuvant therapy in patients with FIGO stage IB–IIA cervical cancer. A total of 200 patients who underwent radical hysterectomy were...

FHL3 Regulates Vascular Smooth Muscle Cell Phenotypic Switching Through the MRTFB-SRF Signaling Axis

Genome-wide association studies have uncovered many coronary artery disease (CAD) loci, but mechanisms linking risk variants to vascular biology remain unclear. We screen candidate causal CAD genes for regulators of the vascular smooth muscle cell (VSMC) contractile phenotype usi...

Development and evaluation of a novel experimental autoimmune prostatitis model induced by a prostate-specific antigen mixture in rats

Objective To develop a novel experimental autoimmune prostatitis (EAP) model in rats using a prostate-specific antigen (PSA) mixture and to determine the optimal dose by evaluating the dose-dependent effects. Methods Male SD rats were divided into control (saline), low-dose (0.1...

Comparative efficacy and toxicity of two versus three induction chemotherapy cycles in locally advanced nasopharyngeal carcinoma: a propensity score matching analysis

Abstract Background For patients with locally advanced nasopharyngeal carcinoma (LA-NPC), the optimal number of cycles of induction chemotherapy (IC) remains uncertain. This study aimed to assess the efficiency and toxicity of different cycles of IC in LA-NPC patients. Methods Th...