Shantou Central Hospital

Linking centromere stretch to SAC signaling in mammalian oocytes with insights from modified kinetochore model

Abstract The spindle assembly checkpoint (SAC) monitors kinetochore-microtubule interactions to ensure accurate chromosome segregation. In mitosis, investigation of its silencing at anaphase centers on whether attachment or tension is the key signal, while in meiosis for mammalia...

Influencing factors and the pathway analysis of demoralization among stroke patients: a cross-sectional study

Demoralization was found to seriously harm patients‘ disease outcomes and quality of life, and could even lead to suicidal ideation and shorten life expectancy. Understanding the level of demoralization in stroke patients and exploring its mechanism wasconsidered not only conduci...

Large-scale esophageal cancer screening through noncontrast computed tomography and artificial intelligence

The absence of accurate, noninvasive, scalable screening tools keeps early esophageal cancer (EC) detection a global health challenge. Although noncontrast computed tomography (NC CT) is widely accessible, the esophagus is a hollow tubular structure prone to collapse and motion a...

In vitro and in vivo evaluation of YIGSR-modified liposomes co-loaded with doxorubicin and 5F

Targeted liposomes represent an excellent drug delivery system for enhancing therapeutic effects. In this study, a novel YIGSR-modified liposomal formulation co-encapsulating two antitumor drugs, doxorubicin (DOX) and ent-11α-hydroxy-15-oxo-kaur-16-en-19-oic-acid (5F), was develo...

Neoadjuvant Anbenitamab and HB1801 in ERBB2 -Positive Breast Cancer

IMPORTANCE The combination of neoadjuvant taxanes with trastuzumab and pertuzumab remains the cornerstone treatment strategy in ERBB2 -positive breast cancer. Anbenitamab (a ERBB2 -biparatopic antibody that induces profound receptor clustering) and HB1801 (a solvent-free albumin-...

Development and evaluation of a novel experimental autoimmune prostatitis model induced by a prostate-specific antigen mixture in rats

Objective To develop a novel experimental autoimmune prostatitis (EAP) model in rats using a prostate-specific antigen (PSA) mixture and to determine the optimal dose by evaluating the dose-dependent effects. Methods Male SD rats were divided into control (saline), low-dose (0.1...