Shanghai Veterinary Research Institute

Galactosylated Camptothecin (Gal-CPT) as a New Anticancer Prodrug Sequentially Activated by Dual Tumor-Specific Enzymes

Abstract Camptothecin (CPT) and its clinically used derivatives are still plagued by severe off-target toxicities. In this study, we designed a galactosylated CPT (Gal-CPT) prodrug incorporating an enzymatically cleavable diethylene glycol linker. In vivo experimental results ver...

SAMSN1 restricts Japanese encephalitis virus replication by recruiting TRIM21 to degrade viral proteins and activate the interferon pathway

Abstract Japanese encephalitis virus (JEV), a zoonotic mosquito-transmitted flavivirus, induces human encephalitis and swine reproductive diseases. No antiviral drugs or treatments exist for flavivirus infections, which cause severe symptoms. Even though some host proteins can su...

An iPAS-optimized phage cocktail delivered by a skin-derived ECM hydrogel for antimicrobial-regenerative treatment of seawater immersion wounds infected with MDR E. coli

Seawater immersion (SWI) wounds are prone to multidrug-resistant (MDR) bacterial infections and impaired tissue repair, yet dual-function wound dressings that combine robust antibacterial activity with proregenerative capacity remain scarce. Through shotgun metagenomic sequencing...

Self-assembling trivalent nanoparticle vaccine enables multivalent antigen display and potent cross-protection against fowl adenovirus serotypes 4, 8b, and 11

Hepatitis-hydropericardium syndrome, caused by fowl adenovirus serotype 4(FAdV-4), and inclusion body hepatitis, caused by fowl adenovirus 8b and 11 (FAdV-8b and FAdV-11), have become widespread in China, resulting in substantial economic losses. Vaccination remains one of the mo...