Institution
Shanghai University of Medicine and Health Sciences
Recent research
- Health & MedicineOpen access
ABSTRACT Chronic stress potentially accelerates aging and increases age‐related disease risk. However, the underlying mechanisms and organ specificity remain unclear. Utilizing a 12‐month unpredictable chronic mild stress (UCMS) mouse model, we revealed chronic stress significant...
- Biology
Deep fusion for multimodal subtype classification of major depressive disorders based on TSCANet
Major Depressive Disorder (MDD) represents a major global health burden, characterized by high recurrence rates and an increased risk of suicide. Traditional clinical diagnoses rely primarily on subjective scales, which limits their objectivity in accurately distinguishing MDD su...
- Health & MedicineOpen access
Multilevel factors predicting medication adherence among gout patients in China
Adherence to urate-lowering therapy (ULT) is crucial for gout management, yet it remains suboptimal worldwide, particularly in China where relevant data are scarce. This study investigates the prevalence and predictors of medication adherence among Chinese gout patients receiving...
- Biology
Background This study investigated associations between MSH5 polymorphisms and autoimmune thyroid disease (AITD) susceptibility.Methods We genotyped rs409558 and rs707939 in 943 patients with AITD, including 591 with Graves’ disease (GD) and 352 with Hashimoto’s thyroiditis (HT),...
- Health & MedicineOpen access
Abstract Background Children with cerebral palsy (CP) and other central nervous system (CNS) impairments often have limitations in walking capacity and gross motor function. Robot-assisted gait training (RAGT) is increasingly used in pediatric rehabilitation, but existing evidenc...
- Health & MedicineOpen access
From peak performance to practical robustness in radiopharmaceutical design
Radiopharmaceutical research and development has been largely driven by the pursuit of high radiochemical yield (RCY) under optimized laboratory conditions. However, this emphasis on peak performance often overlooks a critical translational bottleneck: insufficient robustness und...
- BiologyOpen access
Abstract Background Acute kidney injury (AKI) affects a considerable proportion of patients that represents a major challenge for clinical treatment. Gut microbiota metabolites have been reported to attenuate acute kidney injury (AKI), yet their underlying mechanisms remain large...
- Health & MedicineOpen access
Abstract Background Digital therapeutics (DTx), a new type of intervention presented in the last few years, can be used to provide patients with access to evidence-based therapeutic interventions using high-quality software programs to achieve the purpose of treating, managing, o...
- Materials & Energy
Abstract Rising atmospheric CO2 levels and pervasive pharmaceutical wastewater contamination are two pressing global environmental challenges. Integrating CO2 reduction with the organic pollutant degradation in a single photocatalytic system is an attractive strategy for collabor...
- BiologyOpen access
Circadian rhythms have been implicated in the regulation of cardiovascular physiology and disease. Disruption of circadian signaling has been linked to exaggerated neointimal hyperplasia and delayed endothelial repair. Bmal1, a core component of the molecular clock, plays a criti...
- Engineering & TechnologyOpen access
MRgFUS-enabled nanogel platform for synergstic chemo-immunotherapy in glioblastoma
Glioblastoma multiforme (GBM) is a highly aggressive brain tumor with poor prognosis and limited responsiveness to temozolomide (TMZ)-based chemoradiotherapy. Treatment remains hindered by the blood-brain barrier (BBB), blood-brain tumor barrier (BBTB), acquired TMZ resistance, a...