Shanghai Sunshine Rehabilitation Center

Balance function and cortical activation patterns following speed- and duration-adapted robotic exoskeleton training in people with subacute stroke

Abstract Background Robotic exoskeleton training (RET) parameters in stroke rehabilitation exhibit variability, highlighting the need for optimization to improve therapeutic efficacy. This study quantified the effects of speed- and duration-adapted RET on balance function and cor...

Nuclear NAD + promotes innate immune memory by inhibiting KDM5A-dependent histone demethylation

Trained immunity is tightly regulated by metabolic and epigenetic reprogramming, yet how these changes are orchestrated at the chromatin level to establish long-term innate immune memory is not fully understood. Here, we show that induction of trained immunity elevates nuclear le...

Anti-SEZ6L2 antibody-associated autoimmune encephalitis initially misdiagnosed as cerebral infarction: a case report and narrative literature review

Anti-SEZ6L2 antibody-associated autoimmune encephalitis is a rare immune-mediated disorder characterized predominantly by progressive cerebellar ataxia. Due to its rarity and variable presentation, it remains under-recognized and is frequently misdiagnosed as cerebrovascular or n...

Mitochondrial dysfunction in microglia: a novel perspective of depression pathogenesis

Major depressive disorder is a prevalent psychiatric disease that is closely linked to chronic low-grade neuroinflammation, which is primarily driven by microglia, the primary resident immune cells in the brain. Accumulating studies started to reveal that mitochondria, the powerh...

Myocardial tissue characteristics assessed by multiparametric CMR in hyperthyroid patients with suspected cardiac involvement

Abstract Background Hyperthyroidism is reportedly associated with increased cardiovascular risk and heart failure. However, a definite association between hyperthyroidism and cardiomyopathy has not been reported. This study aimed to analyze alterations in myocardial tissue charac...

NLRP3 inflammasome activation drives psychological stress-induced TMJOA through chondrocyte pyroptosis

Psychological stress, an increasingly serious social problem, is widely recognized as a contributing factor to temporomandibular joint disorders (TMDs). However, whether it could directly cause temporomandibular joint osteoarthritis (TMJOA) is still unknown. This study aimed to i...

Facing inevitable decline: a systematic review and thematic synthesis of progression-related fears in amyotrophic lateral sclerosis

Abstract Background Amyotrophic lateral sclerosis (ALS) is characterised by inevitable and continuous deterioration, yet the psychological experience of anticipating future decline has not been systematically synthesised. Although qualitative studies have described loss, uncertai...

Long‑term Tai Chi practice promotes cortical synchronization in postural control among older adults

Tai Chi has become increasingly popular for its health benefits in postural control. Evidence on cortical adaptation and regulation in postural control in long‑term Tai Chi practitioners remains limited. The aim of this study was to determine whether cortical adaptation and postu...

Prophylactic administration of caffeine reduces bronchopulmonary dysplasia in very preterm infants: a single center, randomized controlled trial

Caffeine has been widely used to prevent apnea in very preterm infants (VPIs), but it is not clear whether prophylactic administration of caffeine can prevent bronchopulmonary dysplasia (BPD) in VPIs. This single-center, randomized clinical trial recruited very preterm neonates (...

Electrical Pudendal Nerve Stimulation as an Initial Neuromodulation Strategy for Neurogenic Urinary Retention

Background and objective Chronic neurogenic urinary retention often requires assisted emptying and remains challenging to treat. We evaluated whether electrical pudendal nerve stimulation (EPNS) improves bladder emptying and compared short-term outcomes with a standard sacral neu...

The making of cells and organs in xenogeneic animal bioreactor

ABSTACT: For patients with end-stage organ dysfunction, organ transplantation is the only viable treatment option. However, the most significant challenge at present is the severe shortage of donor organs, and no technology exists that allows for long-term, sustainable organ gene...