Shanghai Stomatological Hospital

Reversing KDM6A phosphorylation-driven epigenetic suppression restores pyroptosis and synergizes with anti-PD-1 therapy in HNSCC

Abstract Immune checkpoint blockade (ICB) has revolutionized head and neck squamous cell carcinoma (HNSCC) treatment. Yet, a major barrier to response is that tumor cells are epigenetically reprogrammed to resist immunogenic cell death, particularly pyroptosis. To elucidate how t...

Structural characteristics of the temporomandibular joint in temporomandibular joint disorder syndrome: a preliminary cross-sectional study based on MRI

Temporomandibular joint disorder syndrome (TMD) is a prevalent oral-maxillofacial condition. The Diagnostic Criteria serve as a widely used diagnostic framework for TMD with high specificity, yet its sensitivity requires further optimization. In contrast, magnetic resonance imagi...

Custom prosthetic rehabilitation of ocular defects with a digital workflow

Abstract Purpose To use digital technologies, including high-resolution imaging, computer-aided design (CAD), and three-dimensional (3D) printing, to introduce a streamlined process by enabling rapid, reproducible, and cost-effective digital fabrication of orbital prostheses, the...

Dentofacial Orthopedic Treatment vs. Adenotonsillectomy in Children with Mild to Moderate OSA and Mandibular Retrognathia: A Randomized Controlled Trial

Background/Objectives: Pediatric obstructive sleep apnea (OSA), particularly when accompanied by mandibular retrognathia, presents as a complex, multifactorial condition. Dentofacial orthopedic treatment (DOT) has gained increasing clinical attention; however, high-level evidence...

Dental caries among 12-year-old adolescents in shanghai: a cross-sectional study on prevalence, severity, and associated risk factors

This study aimed to assess the prevalence, severity, and associated factors of dental caries in permanent teeth among 12-year-old adolescents in Shanghai, China. A cross-sectional study was conducted in 2021 among 1,305 adolescents from six randomly selected districts. Clinical e...

Methionine addiction in oral squamous cell carcinoma: a metabolic vulnerability targeted by engineered bacteria

Metabolic reprogramming is a defining hallmark of malignant transformation, and tumor-specific amino acid addiction has emerged as a promising therapeutic axis for precision oncology. Oral squamous cell carcinoma (OSCC) is an aggressive head and neck malignancy marked by limited...