Shanghai Skin Disease Hospital

Surgical management of dissecting cellulitis of the scalp: a narrative review of techniques, patient selection, and integration with medical therapy

OBJECTIVE: To summarize surgical objectives, indications, technical principles, limitations and reconstructive considerations for dissecting cellulitis of the scalp (DCS), and explicitly distinguish DCS‑specific evidence from data extrapolated from hidradenitis suppurativa (HS)....

Photo‐Controlled Treatment for Psoriasis‐Like Skin Lesions by UVB‐Photoactivated Hydrogen Sulfide Donors and Pterostilbene

ABSTRACT Smart and efficient drug delivery is always desirable, especially for chronic diseases, such as psoriasis. We developed an ultraviolet B (UVB) light‐triggered scaffold, 1,4,2‐dioxazol‐5‐thione (DOT), for the controlled release of hydrogen sulfide (H 2 S), a pivotal endog...

Detection of Treponema pallidum DNA in cerebrospinal fluid and plasma across all stages of syphilis in HIV-negative patients: prevalence and clinical correlates

Treponema pallidum ( T. pallidum ) can invade the central nervous system (CNS), yet the prevalence and clinical correlates of CSF T. pallidum DNA positivity across all stages of syphilis remain incompletely characterized. Paired CSF and plasma samples were collected from 155 untr...

Supramolecular Salicylic Acid Chemical Peeling Combined with Supramolecular Active Zinc for Malassezia Folliculitis: Efficacy and Safety from a Multicenter, Single-Arm Trial

Traditional antifungal therapy for Malassezia folliculitis (MF) is often associated with high recurrence rates and limited long-term options. This study evaluated the efficacy and safety of 30% supramolecular salicylic acid (SSA) combined with supramolecular active zinc (SAZ) in...

Treatment response to systemic therapies in pediatric-onset versus adult-onset psoriasis: a longitudinal real-world study

Background Psoriasis may present with onset in childhood or adulthood, reflecting distinct clinical patterns. Whether treatment response differs between these groups remains unclear, particularly across systemic therapies in real-world settings.Objectives To compare longitudinal...

Immunophenotypic profiling reveals selective activation and differentiation-associated immune perturbations in acute herpes zoster and exploratory correlates of postherpetic neuralgia risk

Herpes zoster (HZ) is caused by varicella–zoster virus (VZV) reactivation and can be complicated by postherpetic neuralgia (PHN). Although cellular immunity is central to VZV control, early peripheral immune correlates associated with PHN risk remain incompletely defined. In this...

Efficacy and Safety of the First Adalimumab Biosimilar in Chinese Children with Severe Plaque Psoriasis: The PISCES Study, a Multicenter Prospective Study

Adalimumab, a monoclonal antibody targeting tumor necrosis factor-alpha, has been approved for the treatment of severe plaque psoriasis in children aged 4 years and older. Data on its use in the clinical management of pediatric psoriasis in China remains limited. This study is th...

Efficacy and Safety of Recibokibart, an Interleukin-36 Receptor Antibody, in Generalized Pustular Psoriasis: A Phase 2 Randomized Trial

BACKGROUND: Generalized pustular psoriasis (GPP) is a rare, severe inflammatory skin disease characterized by acute flares. Recibokibart is a humanized IgG1 monoclonal antibody targeting the interleukin-36 (IL-36) receptor. In a phase 1b open-label study, a single intravenous dos...

L-arginine alleviates polycystic ovary syndrome restore ovulation and androgen levels by regulating gut microbiota

Abstract Emerging research highlights the crucial role of gut microbiota and its metabolites in managing metabolic disorders, implicating their contribution to the pathophysiology of polycystic ovary syndrome (PCOS). The present study employed a multi-omics research approach enco...

Clinical predictors of early treatment response across systemic therapies in psoriasis: a prospective cohort study

Background Baseline clinical factors may help estimate early response in psoriasis, but real world evidence across biologics, methotrexate, and phototherapy remains limited. We used SPEECH registry data to evaluate factors associated with Physician Global Assessment (PGA) ≤ 1 at...

Lesions Reported as Plaque‐Like CD34 ‐Positive Dermal Fibroma Reveal Two Reproducible Clinicopathologic Patterns: Two Cases and Literature Review

Plaque-like CD34-positive dermal fibroma (PDF), which historically overlaps with medallion-like dermal dendrocyte hamartoma (MDDH), is a rare benign CD34-positive spindle-cell lesion with highly variable clinicopathologic descriptions. We analyzed two adult-onset cases and review...