Shanghai Sixth People's Hospital

Sex-Specific Associations of Gestational OPE Exposure with Offspring Digit Ratio: A Birth Cohort Study

Abstract The effect of prenatal organophosphate esters (OPEs) exposure on offspring reproductive development and the potential role of the placenta remain unclear. We investigated the associations of prenatal OPE exposure with the second-to-fourth digit ratio (2D:4D) and the medi...

Expert Consensus on Robot-Assisted Vascularized Bone Grafting for the Treatment of Early-Stage Osteonecrosis of the Femoral Head

Osteonecrosis of the femoral head (ONFH) remains a progressive clinical challenge that predominantly affects young and active adults between 20 and 50 years of age. Without timely and effective surgical intervention, natural disease progression leads to structural subchondral fra...

Skeletal Muscle DPT Ameliorates Obesity and Metabolic Dysfunction via the PERK/eIF2α/ATF4-GDF15 Axis

Skeletal muscle plays a pivotal role in maintaining metabolic homeostasis by acting as a primary site for glucose disposal and insulin-mediated energy use. Here, through RNA sequencing of skeletal muscle from individuals with normal weight versus obesity, we identified that the e...

Persistent Hypoperfusion on Post‐Recanalization Digital Subtraction Angiography Perfusion Maps in Anterior Circulation Large Vessel Occlusion

Background Despite high recanalization rates with endovascular thrombectomy for large vessel occlusion stroke, a large proportion of patients remain disabled. This study aims to investigate the clinical impact of persistent hypoperfusion that was detected immediately after recana...

From Limb Salvage to Function

Mangled extremities resulting from high-energy trauma have long been one of the most formidable challenges in orthopedic trauma and microsurgery. Historically, treatment success was measured by anatomic limb survival. However, clinical practice has demonstrated that a nonfunction...

Pola-R-CHP in previously untreated DLBCL with international prognostic index score 0–1: a multicenter real-world retrospective study in China

Abstract Purpose Approximately 30% of newly diagnosed diffuse large B-cell lymphoma (DLBCL) cases are categorized as low-risk by the international prognostic index (IPI). Polatuzumab vedotin, rituximab, cyclophosphamide, doxorubicin, and prednisone (Pola-R-CHP) has demonstrated e...

Multiphysics modeling of chitosan nanocarrier thrombolysis in human arterial occlusion: insights into carrier retention and dosing strategy

Objectives To develop a human-scale multiphysics model for comparative evaluation of thrombolytic nanocarrier performance and dosing strategies under clinically relevant arterial conditions. Methods We coupled a systemic pharmacokinetic-pharmacodynamic model with one-dimensional...

Metabolic-epigenetic nanoregulator attenuates a folate-deficiency-associated senescence phenotype in intervertebral disc degeneration

Intervertebral disc degeneration (IVDD) is increasingly recognized as an aging-associated disorder driven in part by nucleus pulposus cell (NPC) senescence, yet the nutrient-sensitive metabolic defects that sustain this state remain poorly understood. Here, we investigated impair...

Between desire and constraint: reproductive intentions among working mothers in urban Shanghai—a qualitative study

Research on fertility intentions has largely focused on individual-level predictors such as income, education, and childcare burden, yet less attention has been paid to how these factors are embedded in and shaped by broader social systems. Drawing on in-depth interviews with 15...

Intelligent multimodal classification of infantile vascular diseases based on ultrasound images

Infantile hemangiomas (IH) and venous malformations (VMs) often exhibit overlapping echogenic features in grayscale ultrasound images, necessitating color Doppler ultrasound for accurate diagnosis. Furthermore, some venous malformation patients develop painful phleboliths (vein s...

Targeted degradation of RAGE restores microglial homeostasis and rescues cognitive deficits in 3xTg-AD mice

Chronic neuroinflammation and microglial dysfunction lie at the core of Alzheimer’s disease (AD) pathogenesis. The Receptor for Advanced Glycation End-products (RAGE) serves as a pivotal upstream driver of this inflammatory cascade and associated oxidative stress. However, conven...

Hepatic PDIA5 improves hyperglycaemia and insulin resistance through stabilisation of ATF6

Dysregulation of hepatic glucose production, primarily driven by aberrantly elevated gluconeogenesis, is a core pathological feature of type 2 diabetes. However, the molecular mechanisms governing this process remain incompletely understood. Protein disulfide isomerase A5 (PDIA5)...

Multicenter evaluation of Coyote FlashDetect LyocartE multiplex assays for six respiratory pathogens: a comparative analysis with Sansure and Cepheid assays

ABSTRACT Respiratory diseases caused by common respiratory pathogens, such as influenza A/B (Flu A/B), severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), respiratory syncytial virus (RSV), adenovirus (ADV), and Mycoplasma pneumoniae (MP), share many of the same symptom...

Spinopelvic alignment changes after unilateral total knee arthroplasty associated with functional recovery

Abstract Background The biomechanical interaction between knee pathology and spine–pelvis alignment in advanced knee osteoarthritis (KOA) has received increasing attention. This study evaluated short-term changes in spinopelvic alignment after unilateral total knee arthroplasty (...

Coronary atherosclerosis, myocardial perfusion, and interstitial fibrosis between diabetic and nondiabetic patients with stable chest pain: a propensity score matching study

OBJECTIVES: To evaluate the effect of diabetes mellitus on coronary atherosclerosis, myocardial perfusion, and interstitial fibrosis using cardiac CT. METHODS: This study included 409 diabetic patients with stable chest pain who prospectively underwent coronary CT angiography (CC...

SIRT3-dependent mitochondrial redox homeostasis protects against age-related tendon degeneration

Aims: Mitochondrial redox homeostasis is closely linked to the ageing processes of tendons, whether in normal or pathological conditions. This study employed an innovative approach to examine the role of sirtuin 3 (SIRT3) in mitochondrial dysfunction in the aged murine supraspina...

An interpretable fecal microbiota-based GBM-SHAP machine-learning model for distinguishing ankylosing spondylitis from healthy controls

Previous studies have identified associations between ankylosing spondylitis (AS) and the gut microbiota. This retrospective secondary analysis aimed to develop and interpret a fecal microbiota-based machine-learning model for distinguishing AS samples from healthy-control sample...

Language-enhanced generative modeling for amyloid PET synthesis from MRI and blood biomarkers.

Assessment of amyloid pathology in Alzheimer's disease (AD) often relies on amyloid-beta positron emission tomography (Aβ-PET), but its clinical use is limited by cost and accessibility. We developed a language-enhanced generative framework to synthesize Aβ-PET images from T1-wei...

Treatment of Severe Obstructive Sleep Apnea With a Domestic Implantable Hypoglossal Nerve Stimulator: A Case Report

ABSTRACT Background Implantable hypoglossal nerve stimulation (HNS) is an established neuromodulatory therapy for obstructive sleep apnea (OSA) in patients intolerant to continuous positive airway pressure (CPAP). However, no domestically developed HNS system has been clinically...

A Non-Invasive Transtympanic Bioadhesive Hydrogel for Sustained Delivery of Dexamethasone in Otitis Media Effusion Therapy

Abstract Otitis media with effusion (OME) is a highly prevalent condition characterized by persistent inflammatory effusion in the middle ear cavity. The clinical management of OME remains challenging due to the anatomical inaccessibility of the middle ear, which limits drug effi...