Shanghai Sixth People's Hospital

Language-enhanced generative modeling for amyloid PET synthesis from MRI and blood biomarkers.

Assessment of amyloid pathology in Alzheimer's disease (AD) often relies on amyloid-beta positron emission tomography (Aβ-PET), but its clinical use is limited by cost and accessibility. We developed a language-enhanced generative framework to synthesize Aβ-PET images from T1-wei...

Treatment of Severe Obstructive Sleep Apnea With a Domestic Implantable Hypoglossal Nerve Stimulator: A Case Report

ABSTRACT Background Implantable hypoglossal nerve stimulation (HNS) is an established neuromodulatory therapy for obstructive sleep apnea (OSA) in patients intolerant to continuous positive airway pressure (CPAP). However, no domestically developed HNS system has been clinically...

Nanocatalytic anti-inflammatory therapy for alleviating rheumatoid lesions with endothelial cell-derived hydrosilicene

Severe inflammatory damage of soft tissues and progressive bone destruction are hallmark features of rheumatoid arthritis (RA), in which over-activated neutrophils and excessive neutrophil extracellular traps (NETs) play a pivotal role during the early stages of the disease. Conv...

A Non-Invasive Transtympanic Bioadhesive Hydrogel for Sustained Delivery of Dexamethasone in Otitis Media Effusion Therapy

Abstract Otitis media with effusion (OME) is a highly prevalent condition characterized by persistent inflammatory effusion in the middle ear cavity. The clinical management of OME remains challenging due to the anatomical inaccessibility of the middle ear, which limits drug effi...

Noninvasive 3D mapping of tissue stress using reverberant shear wave

Abstract Mechanical stress is a fundamental aspect of soft tissues that influences cellular behavior and tissue integrity, yet noninvasive imaging of stress in vivo remains a major challenge. Conventional magnetic resonance elastography (MRE) measures tissue stiffness but not str...

ABHD11-Mediated mtDNA Transcription Restored Mitochondrial Function to Attenuate Cardiomyocyte Ferroptosis After Myocardial Infarction

BACKGROUND: Cardiomyocytes exhibit marked susceptibility to ferroptosis after myocardial infarction (MI), rendering ferroptosis inhibition a promising therapeutic strategy to mitigate ischemic myocardial injury. Although mitochondrial dysfunction is recognized as a core driver of...

Clinical application of a novel upper limb restraint device in free scapular flap transplantation surgery: a prospective study

This study aims to compare the clinical efficacy of a traditional upper limb restraint method versus a novel upper limb restraint device, evaluating their respective outcomes in scapular flap surgery. Thirty patients who underwent circumflex scapular flap surgery in our hospital...

Network analysis of frailty, sleep quality, and life satisfaction in older patients: a cross-sectional study stratified by chronic disease burden

Abstract Background Multimorbidity and chronic disease burden are common among older patients and are closely associated with frailty, poor sleep, and reduced subjective well-being. However, total-score-based analyses may obscure item-level interactions across health domains. Thi...

Fingolimod overcomes cisplatin resistance in esophageal squamous cell carcinoma by targeting NUP54 to disrupt homologous recombination repair

Cisplatin resistance is a major obstacle in the treatment of esophageal squamous cell carcinoma (ESCC). To address this challenge, we screened a U.S. Food and Drug Administration (FDA)-approved drug library and identified fingolimod, an immunomodulatory agent, as a potent inhibit...