Shanghai Pulmonary Hospital

Systemic artery-to-pulmonary artery fistulas and recurrence of noncancer-related hemoptysis after bronchial artery embolization: a retrospective study

To investigate the clinical and angiographic characteristics of systemic artery-to-pulmonary artery fistulas (SA-PAFs) in patients with noncancer-related hemoptysis undergoing bronchial artery embolization (BAE), and to assess their associations with procedural outcomes and recur...

Pulmonary Tropheryma whipplei infection in a patient with systemic lupus erythematosus: diagnosis supported by BALF tNGS with subsequent doxycycline-based treatment: a case report

Whipple’s disease is a rare systemic infection caused by Tropheryma whipplei ( T. whipplei ). Pulmonary involvement is uncommon and may mimic sarcoidosis, tuberculosis, or malignancy, delaying diagnosis. Pulmonary presentations may be atypical and nonspecific. We report the case...

Donor-Type-Dependent Heterogeneity of Ischemia–Reperfusion Injury in Lung Transplantation: A Multi-Cohort Transcriptomic Interaction Analysis of DCD Versus DBD Lungs

Background: Donation after circulatory death (DCD) and donation after brain death (DBD) donor lungs are widely used in lung transplantation yet managed as equivalent with respect to ischemia–reperfusion injury (IRI), despite fundamentally different ischemic backgrounds: warm isch...

Targeting endothelial CYP3A5 in lung adenocarcinoma remodels the immunosuppressive microenvironment via VEGF inhibition: Mechanistic insights from Diosmetin

The tumor endothelium not only promotes angiogenesis but also actively fosters an immunosuppressive microenvironment in lung adenocarcinoma (LUAD). Cytochrome P450 enzymes, particularly CYP3A5, have emerged as potential regulators of endothelial function, yet their role in shapin...

Balloon pulmonary angioplasty combined with riociguat for the treatment of inoperable chronic thromboembolic pulmonary hypertension (PRACTICE study)

Recent overseas prospective studies have confirmed the efficacy of BPA in inoperable CTEPH, but studies from China remain limited. Single center, randomized controlled trial enrolling patients with inoperable CTEPH, assigned 2:1 to BPA plus riociguat (B) or riociguat monotherapy...

The Efficacy of Adjuvant EGFR-TKI Therapy for Stage IA Lung Adenocarcinoma with EGFR Mutations: A Retrospective Cohort Study

Abstract Introduction Surgical resection is the standard for early-stage lung adenocarcinoma (LUAD), but recurrence remains a risk for patients with epidermal growth factor receptor (EGFR) mutations. The efficacy of adjuvant EGFR tyrosine kinase inhibitors (EGFR-TKIs) in stage IA...

Anti-cancer drug clinical research

Abstract Malignant tumors are major diseases that seriously threaten human health, and the unmet clinical demand for treatments in the field of oncology has been persistently large. The research and development of new antineoplastic drugs has become a powerful means to address th...

Associations of menstrual cycle length with GDM and gestational hypertension in frozen embryo transfer

Prolonged menstrual cycles may indicate potential cardiometabolic conditions; however, there are limited data on how these associations vary among women without polycystic ovary syndrome (PCOS) undergoing in vitro fertilization (IVF). In this study, we aimed to investigate the as...

Longitudinal spatial multi-omics delineates tumor microenvironment remodeling across sequential EGFR-TKIs in EGFR-mutant NSCLC

Abstract Background Resistance to therapy is a frequent occurrence in patients with epidermal growth factor receptor (EGFR)-mutant non-small-cell lung cancer (NSCLC) who are treated with EGFR tyrosine kinase inhibitors (EGFR-TKIs). However, spatial information on how the tumor mi...

Galectin-3 worsens microglia-mediated synaptic engulfment and neuroinflammatory responses after traumatic brain injury

Activated microglia-mediated aberrant synaptic phagocytosis is an important contributor to neurological deficits following traumatic brain injury (TBI). Galectin-3 (Gal-3), a pivotal regulator of microglial activity, is increased after TBI. However, its role in microglia-mediated...

Post-traumatic growth in people with cancer: A meta-synthesis of qualitative studies

This qualitative meta-synthesis systematically reviewed studies on post-traumatic growth (PTG) in people with cancer. A comprehensive search of nine databases was conducted up to February 2025. Following PRISMA guidelines, the methodological quality of included studies was assess...

Multi‐Omics Integration Identifies a CDH3‐Associated Malignant Epithelial State and Immunosuppressive Niche to Predict Prognosis in Thymic Epithelial Tumors

ABSTRACT Thymic epithelial tumors (TETs) are rare and heterogeneous malignancies whose aggressive epithelial states and microenvironmental organization remain poorly defined. Here, we integrated single‐cell RNA sequencing, spatial transcriptomics, multiplex immunofluorescence, bu...

Mitochondrial Omics in Macrophage Foam Cell Formation and Atherosclerosis

Atherosclerotic cardiovascular disease (ASCVD) is a leading cause of death worldwide, with atherosclerosis serving as the core pathological mechanism driving ischemic heart disease, ischemic stroke, and peripheral artery disease. Macrophages play a central role in atherosclerosis...

Mefatinib versus gefitinib as a first-line treatment for EGFR-mutated non-small cell lung cancer: a randomized, double-blind, multicenter phase III study

Mefatinib, a novel second-generation epidermal growth factor (EGFR) tyrosine kinase inhibitor that has shown promising antitumor activity in targeting non-small cell lung cancer (NSCLC) with common and uncommon EGFR- activating mutations. In this phase III, randomized, double-bli...

Chemotherapy remains effective in ALK-TKI therapy: a retrospective analysis in ALK-positive advanced NSCLC

Tyrosine kinase inhibitors (TKIs) are the standard therapy for advanced non-small cell lung cancer (NSCLC) harboring anaplastic lymphoma kinase (ALK) fusions. However, acquired resistance remains a major challenge, necessitating strategies to prolong therapeutic efficacy. This st...

Clinical utility of molecular residual disease detection in early-stage resected EGFR-mutated non-small cell lung cancer

Molecular residual disease (MRD), detected through circulating tumor DNA, has emerged as a promising biomarker for surveillance in patients with early-stage non-small cell lung cancer (NSCLC) following curative-intent resection. Here we report the MRD analysis from the phase 3 EV...

Stromal Cells Recruitment by Sono‐Piezoelectric/Pyroelectric Peptide Hydrogels Promotes Bone Regeneration After Postsurgical Osteosarcoma Recession: A Real‐World‐Matched Study

ABSTRACT Currently, the elimination of postsurgical osteosarcoma (OS) and defect repair are still separately explored, which is unlike real‐world clinical scenarios. Inadequate bone marrow stromal cells (BMSCs) compromise their repair and antitumor efficiencies. Here, PFSSTKT (PF...

The landscape and plasticity of transposable element expression in an adult stem cell of high physiological and clinical significance

Abstract Transposable elements (TEs) contribute to diverse aspects of stem cell biology, particularly in germline and pluripotent stem cells, which typically exhibit more open chromatin. In human adult stem cells (ASCs), however, a comprehensive framework describing the landscape...

BCL9 inhibition promotes fibroblast lipogenesis by regulating macrophage–fibroblast interactions to attenuate pulmonary fibrosis

Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal interstitial lung disease with an urgent need for novel therapeutic strategies. M2 macrophage-derived TGF-β1 promotes fibroblast myogenesis, contributing to IPF pathogenesis. Targeting macrophage polarization and fibr...