Shanghai Pudong New Area Gongli Hospital

Sex‐Specific Digital Phenotyping of Lower Urinary Tract Symptoms: A Cross‐Sectional Study of 1586 Adults From 35 Centers in China

ABSTRACT Background and Purpose Lower urinary tract symptoms (LUTS) represent a complex clinical syndrome with significant sexual dimorphism. Traditional “one‐size‐fits‐all” management often overlooks intra‐sex phenotypic heterogeneity. This study utilized unsupervised machine le...

Integrated single-cell and spatial transcriptomic analysis characterizes a TNBC-enriched EP5-associated malignant epithelial program and prioritizes REEP4 in breast cancer

Triple-negative breast cancer (TNBC) exhibits pronounced epithelial-state plasticity, aggressive clinical behavior, and heterogeneous responses to immune checkpoint blockade (ICB)-based neoadjuvant therapy. Bulk transcriptomic analyses cannot resolve epithelial-state heterogeneit...

Sinter-Resistant N-Doped Biomass-Derived Carbon-Supported Pd Catalyst for Hydrogenation of Phenol to Cyclohexanol

Abstract Selective hydrogenation of lignin-derived phenols provides saturated cyclic oxygenates relevant to renewable fuel synthesis. Pd nanoparticles were supported on N-doped biomass-derived carbon (Pd/NBC) and evaluated for consecutive phenol hydrogenation to cyclohexanol. Pd/...

Formula-dependent LDL-C threshold classification and reporting uncertainty in the UK Biobank

Abstract Objectives Calculated low-density lipoprotein cholesterol (LDL-C) is widely reported, but formula-dependent estimation differences may alter classification near decision thresholds. We assessed formula-dependent LDL-C classification relative to direct LDL-C in UK Biobank...

Electrical Pudendal Nerve Stimulation as an Initial Neuromodulation Strategy for Neurogenic Urinary Retention

Background and objective Chronic neurogenic urinary retention often requires assisted emptying and remains challenging to treat. We evaluated whether electrical pudendal nerve stimulation (EPNS) improves bladder emptying and compared short-term outcomes with a standard sacral neu...

The landscape and plasticity of transposable element expression in an adult stem cell of high physiological and clinical significance

Abstract Transposable elements (TEs) contribute to diverse aspects of stem cell biology, particularly in germline and pluripotent stem cells, which typically exhibit more open chromatin. In human adult stem cells (ASCs), however, a comprehensive framework describing the landscape...