Shanghai Public Health Clinical Center

Depression and anxiety mediate the association between sleep quality and health-related quality of life in people living with HIV

Sleep disturbances are highly prevalent among people living with HIV (PWH) and frequently co-occur with psychiatric comorbidities such as depression and anxiety. Although these factors independently predict health-related quality of life (HRQoL), the extent to which psychiatric s...

Sexual health and healthy aging: the five ‘I’s conceptual framework

Sexual health remains important throughout life, including in older age. This special collection shows that older adults need respectful, inclusive, and culturally appropriate sexual health services. The five ’I’s framework – importance, individuality, inclusion, involvement, and...

Risk Factors for Poor Neurological Outcomes at Discharge in Tuberculous Meningitis: Disease Severity, Host Factors, and Drug Therapy

Introduction: This study investigated independent factors associated with neurological prognosis at discharge in patients with tuberculous meningitis (TBM) and evaluated the impact of intensified treatment regimens. Methods: A retrospective analysis was conducted in 518 TBM patie...

Gut microbiota dysbiosis correlates with reduced drug exposure in patients with multidrug-resistant tuberculosis

Although systemic exposure to anti-tuberculosis agents is critical for therapeutic efficacy, substantial inter-individual variability of drug exposure persists despite standardized dosing. Emerging studies suggest that the gut microbiota may influence drug metabolism and host pha...

Burden of latent tuberculosis infection among people living with HIV in Shanghai, China: a 4-year cohort study

Abstract Background Mycobacterium tuberculosis / human immunodeficiency virus (TB/HIV) co-infection remains a significant global public health challenge. In areas with a lower incidence of TB and HIV, how to elevate screening efficiency while maintaining cost-effectiveness worth...

Effects of Home Caregiving Quality on the Psychological and Behavioral Development of Vulnerable Children Aged 0-3 Years.

=0.041）.In contrast，children with normal development at baseline demonstrated substantially lower risks of subsequent developmental delay. Conclusions Early caregiving quality has an immediate effect on children's psychological and behavioral development，and it continues to in...

An adenovirus-based multiantigen vaccine protects against tuberculosis by coordinating adaptive immunity and curbing immunosuppressive mechanisms

ABSTRACT Given that tuberculosis (TB) remains the leading cause of death from a single infectious agent, and that vaccination is the most effective control strategy, we systematically compared several vaccine construction strategies using a chimpanzee adenovirus vector platform....

HBV re-activation is associated with increased mortality and dysregulation of oxidative and polyamine metabolism in pre-acute-on-chronic liver failure

Abstract Background/Aims Acute-on-chronic liver failure (ACLF) is one of the deadliest complications of chronic liver disease yet treatment options are sparse. In Asia, HBV-reactivation (HBVr) is one of the most common triggers. Recently, HBV-associated ACLF was associated with d...

Dysregulated BCR repertoire and metabolic state of HBsAg-specific B cells in chronic hepatitis B revealed by integrated single-cell analysis

Background: Humoral immunity targeting hepatitis B virus (HBV) surface antigen (HBsAg) is critical for viral clearance. However, the phenotypic, repertoire, and metabolic features of HBsAg-specific B cells in chronic hepatitis B (CHB) remain incompletely defined. Methods: HBsAg-s...

Dentofacial Orthopedic Treatment vs. Adenotonsillectomy in Children with Mild to Moderate OSA and Mandibular Retrognathia: A Randomized Controlled Trial

Background/Objectives: Pediatric obstructive sleep apnea (OSA), particularly when accompanied by mandibular retrognathia, presents as a complex, multifactorial condition. Dentofacial orthopedic treatment (DOT) has gained increasing clinical attention; however, high-level evidence...

Parent–child connectedness and its associations with sexual risk behavior and outcomes among young people: a systematic review and meta-analysis

Significant disparities in the sexual and reproductive health of young people persist globally. Although previous systematic reviews and meta-analyses have largely focused on the effects of parenting practices, such as parent–child communication and parental monitoring, on sexual...