Shanghai Medical Information Center

Development and Validation of a Novel Contact Force‐Integrated Pulsed Field Quantization Index for Pulmonary Vein Isolation in a Porcine Model

ABSTRACT Introduction There is no bipolar‐specific quantitative ablation index currently available to guide pulsed field ablation (PFA). We aimed to develop and validate a novel contact force (CF)‐integrated pulsed field quantization index (PFQI) for real‐time lesion depth predic...

A case of hypertensive retinopathy developing during pembrolizumab treatment for intrahepatic cholangiocarcinoma

To report the first documented case of severe vision loss due to secondary hypertensive retinopathy associated with pembrolizumab therapy, thereby expanding the known spectrum of ocular toxicities from immune checkpoint inhibitors (ICIs). A 54-year-old woman with intrahepatic cho...

Helicobacter pylori infection, hyperuricemia, and serum uric acid levels: The role of metabolic, renal, and inflammatory factors in a large health examination population

Background Helicobacter pylori ( H. pylori ) infection has been linked to several extragastric metabolic disorders. However, its cross-sectional association with hyperuricemia remains uncertain, partly because previous studies have often been limited by small sample sizes and inc...

Availability and equity analysis of China’s National Reimbursement Drug List-negotiated drugs: a national cross-sectional analysis

Ensuring equitable access to innovative drugs is crucial for public health. Despite the inclusion of innovative drugs on China’s National Reimbursement Drug List, disparities in availability persist across regions and healthcare facility levels. This study aims to assess the avai...

The value of combined SATB2 and CDX2 detection in the differential diagnosis of colorectal adenocarcinoma

This study evaluates the diagnostic value of SATB2 and CDX2, used individually and in combination, in the immunohistochemical differential diagnosis of colorectal adenocarcinoma. A retrospective case-control diagnostic accuracy study was conducted, including 122 patients with his...

Comparison and Selection of Network Meta‐Analysis Models for Fitting and Extrapolating Cancer Survival Data

ABSTRACT Aim To assess network meta‐analysis (NMA) model biases under different proportional hazards (PHs) scenarios, compare fitting and extrapolation performance for hazard ratios (HRs) using cancer survival data, identify metrics guiding model selection, and compare extrapolat...

Nanocatalytic anti-inflammatory therapy for alleviating rheumatoid lesions with endothelial cell-derived hydrosilicene

Severe inflammatory damage of soft tissues and progressive bone destruction are hallmark features of rheumatoid arthritis (RA), in which over-activated neutrophils and excessive neutrophil extracellular traps (NETs) play a pivotal role during the early stages of the disease. Conv...