Shanghai Institutes for Biological Sciences

Olink proteomics reveals immuno-inflammatory profile changes and potential regulatory mechanisms of non-suicidal self-injury behavior associated with depression in adolescent

Abstract Background N on- s uicidal s elf- i njury (NSSI) frequently co-occurs with adolescent depression. The underlying immunoinflammatory mechanisms and peripheral biomarkers remain poorly understood. This study aimed to identify plasma proteins associated with NSSI in depress...

Artificial intelligence virtual bone organoids (AIVBOs)

Global population aging has made skeletal disorders a major threat to human health. Solid bone organoids reproduce skeletal physiology and pathology more faithfully than traditional models, yet remain limited in standardisation, real-time monitoring, and high-throughput use. Inte...

Dual Drug-Loaded Enzyme-Responsive Liposomes Exert Specific Modulation on Liver Cancer Cells and Tumor-Associated Macrophages In Vitro

Background: Hepatocellular carcinoma (HCC) is a highly lethal malignancy and remains a major contributor to global cancer mortality. In situ vaccination (ISV) holds great potential for HCC therapy. Still, its efficacy is severely limited by intrinsic antigen scarcity and the tumo...