Shanghai Institute of Organic Chemistry

Preparation of Substituted Phenyl Perfluoro ‐tert ‐butyl Sulfones and Their Use in Nucleophilic Perfluoro ‐tert ‐butylation Reactions

A series of perfluoro‐ tert ‐butyl aryl sulfones are successfully prepared under mild conditions and subsequently employed as reagents for the perfluoro‐ tert ‐butylation of arynes and benzyl bromides, respectively. It is found that the reactions with benzyl bromides generally sh...

Persistent Mn 3+ Sites on Reduced MnO Enable Efficient Syngas Conversion

ABSTRACT Mn‐based materials are widely used for syngas conversion, where MnO is generally regarded as the catalytically active phase under reducing conditions. Yet catalysts derived from different Mn oxide precursors often exhibit markedly different performances despite evolving...

Synthesis of Chiral α-Aminophosphonate Derivatives through Copper(I)-Catalyzed Enantioselective Alkylation

Abstract Efficient methodologies for the catalytic asymmetric synthesis of α-aminophosphonic acid derivatives remain limited, particularly those involving carbon-carbon (C-C) bond formation. Herein, we report a copper(I)-catalyzed enantioselective alkylation of N-protected aminom...

From Direct to Alternating Current Electrosynthesis: Transition-Metal-Catalyzed Oxidative Cross-Coupling with Hydrogen Evolution

Conspectus Electrochemical transition-metal catalysis is an effective yet underexplored platform for molecular construction. Combining the advantages of electrochemically driven oxidation processes with the selectivity control afforded by transition-metal catalysis, this field is...

Structural basis of the transport mechanism of hBGT1

In the kidney and liver, the betaine/γ-aminobutyric acid (GABA) transporter 1 (BGT1) transports betaine to maintain the osmotic balance of renal medullary cells and reduce the toxicity of homocysteine accumulation. In the brain, BGT1 reuptakes GABA from the synaptic cleft into gl...

Cerebellar α-synucleinopathy contributes to Parkinsonian gait and balance impairment in mouse models

Postural instability and gait difficulty (PIGD) represent a debilitating clinical subtype of Parkinson’s disease (PD) that is largely refractory to dopaminergic replacement therapy. While clinical imaging implies that the cerebellum is involved in these axial deficits, the specif...

Palladium-Catalyzed Tandem Dearomative Heck Reaction of N -Propiolyl Indoles or Pyrroles with Aryl Bromides

Abstract An efficient Pd-catalyzed tandem dearomative Heck reaction of N-propiolylindoles or pyrroles with aryl bromides has been developed. The protocol provides access to a series of benzopyrrolizinone and pyrrolizinone derivatives bearing a quaternary stereocenter and a tetras...

Enantioselective Synthesis of Azahelicenes via Rh-Catalyzed C–H Functionalization of 6-Hydroxyisoquinoline Derivatives with Alkynes

Abstract Herein, we report an asymmetric C–H functionalization of 6-hydroxyisoquinoline derivatives and annulation with internal alkynes. The reaction is catalyzed by a chiral cyclopentadienyl (Cp)-Rh complex in combination with a modified chiral amino acid. A series of azahelice...

A Unified Mechanistic Framework for Copper Toxicity in Neutrophils: Metabolic Rewiring, Cell-Death Crosstalk, and Immune Dysfunction

Significance: Copper is an essential redox-active micronutrient, but failure of copper compartmentalization can convert it from a catalytic cofactor into a source of oxidative, proteotoxic, and mitochondrial stress. Neutrophils are a plausible target of this transition because th...

Modular Synthesis of α‐Quaternary Pyrrolines by Pyridoxal‐Catalyzed Sequential Reactions With Precise Chirality Relay

ABSTRACT The construction of molecular architectures bearing two contiguous stereocenters, particularly those featuring a quaternary carbon, remains a significant synthetic challenge. Herein, we report a modular one‐pot, two‐step strategy that combines carbonyl catalysis with seq...

An Isolable Terminal Imido Complex of Platinum

Abstract Late transition-metal imido species serve as key intermediates in a variety of catalytic transformations. However, their transient nature renders isolation challenging, and an isolable platinum terminal imido complex has remained elusive to date. In this work, we present...

Chiral Nanostructured Cobalt Nanoparticles Confined in Zeolite for Syngas Conversion to Liquid Fuels at Low Temperature

ABSTRACT Low‐temperature Fischer–Tropsch synthesis is an energy‐efficient process that converts nonpetroleum carbon sources into liquid hydrocarbon fuels. However, achieving C─C coupling under mild conditions is a significant challenge, primary due to the high energy barriers ass...

TogoPhosTAC as a delivery-ready platform for targeted protein dephosphorylation

Phosphorylation-targeting chimeras (PhosTACs) enable targeted protein dephosphorylation by recruiting phosphatases through induced proximity. However, the direct recruitment of phosphatase subunits or holoenzymes with small molecules remains challenging, as suitable ligands are s...

Stereoelectronically Controlled Regioselective Allylation of Aldehyde Under Photoredox/Chromium Catalysis

ABSTRACT The formation of structurally defined α,γ‐disubstituted allylmetallic intermediate which could undergo regioselective allylation with carbonyl compounds remains a formidable challenge in synthetic chemistry. Although regioselective in situ formation of α,γ‐disubstituted...

Bubble‐Assisted Dynamic Confinement Enables Programmable Solid‐State Photoswitching and Heterogeneous Photoresponsive Architectures

Achieving programmable photoisomerization of azobenzenes in the solid-state remains a long-standing challenge for photoresponsive materials. Here, we introduce a dynamic soft-confinement strategy using bubble-assisted assembly to manipulate molecular aggregation via tunable surfa...