Shanghai Institute of Applied Physics

Programming Hydrophobic Nanocavity of DNA Frameworks for Ultrastable Fluorescent Imaging

ABSTRACT Fluorescent proteins (FPs) are widely used in biological imaging, yet their limited programmability restricts adaptability for advanced nanoscale applications. Synthetic molecular containers offer designable cavities but struggle to simultaneously achieve large dimension...

A nuclear clock synchronized to 229Th

Abstract Atomic clocks have made time and frequency the most precisely measured quantities in physics, progressing from microwave standards that realize the SI second 1 to optical clocks with unprecedented precision 2 . A nuclear clock transfers the frequency reference from an el...

Termination-Dependent Surface States and Magnetic Fingerprints of Chiral Helimagnet Cr1/3TaS2

Abstract Chiral helimagnets based on intercalated transition-metal dichalcogenides, characterized by nanoscale spin ordering, provide a powerful route to engineer chiral spin textures (e.g., the topologically protected magnetic solitons) and explore emergent electronic functional...

Cerebellar α-synucleinopathy contributes to Parkinsonian gait and balance impairment in mouse models

Postural instability and gait difficulty (PIGD) represent a debilitating clinical subtype of Parkinson’s disease (PD) that is largely refractory to dopaminergic replacement therapy. While clinical imaging implies that the cerebellum is involved in these axial deficits, the specif...

Semimetal-Interlayer-Engineered MoSe 2 /1T′-MoTe 2 /WSe 2 Heterostructure for Reconfigurable Rectification and Broadband Multifunctional Photodetection

Abstract Photodetectors based on two-dimensional (2D) van der Waals heterostructures have attracted considerable interest owing to their tunable electronic structures and efficient photoelectric conversion. However, simultaneously achieving low dark current, high photoresponse, a...

Dislocation Engineering Steers Reaction‐Induced Reconstruction of Vanadium Oxides for Selective Oxidation of Ethane

ABSTRACT Catalytic active sites or centers could evolve from their initial form under realistic reaction conditions due to the autonomous behaviors of the constituent atoms to adapt to the surrounding environment. Controlling such adaptability of metal‐oxide‐based catalysts is cr...

Steering Cu Interatomic Distances and Local Steric Environment of Nonporous Coordination Polymers Boosts CO 2 Electroreduction to C 2 Products

ABSTRACT Metal–organic frameworks (MOFs) and porous coordination polymers (CPs) are promising electrocatalysts for CO 2 reduction, but suffer from poor stability and mass transfer limitations at high current densities. While nonporous CPs show efficient CO 2 ‐to‐C 1 conversion wi...

Investigation of Position-Dependent Signal Propagation Delay in Large-Pitch AC-LGAD Using a Two-Dimensional Transmission-Line Model

This paper presents a study of position-dependent signal propagation delay in large-pitch pixelated AC-coupled Low-Gain Avalanche Detectors (AC-LGADs). In AC-LGADs, a continuous resistive N+ layer and segmented AC-coupled readout electrodes enable charge sharing and simultaneous...

Evaluating the Stability of Oxide‐Derived Cu─Sn Catalysts for CO 2 Reduction in Zero‐Gap Electrolyzers

ABSTRACT Bimetallic electrocatalysts hold substantial potential for scaling up CO 2 electroreduction, yet their practical deployment is hindered by a persistent gap between conventional three‐electrode testing and industrially relevant electrolyzer conditions. In this study, we e...

Sensitivity Study of the Reactivity-Equivalent Physical Transformation Method for Fluoride Salt Coolant Pebble Bed Reactor Lattice

Conventional dispersed-particle fuel systems, such as TRISO fuel, exhibit typical double heterogeneity. The Reactivity-equivalent Physical Transformation (RPT) method can convert a double-heterogeneity system into a single-heterogeneity system by simplified geometric modelling. I...

Tracking the baryon number with nuclear collisions

Baryon quantum number is found to be conserved since baryogenesis in the early Universe. Conventionally, each fractionally charged valence quark is understood to carry one-third of a baryon number. An alternative hypothesis posits that baryon number is instead carried by a baryon...

A dual role of PIEZO2 in neuropathic pain: driving peripheral sensitization and enabling mechanical loading-induced analgesia

Mechanotherapy, a form of mechanical loading (ML), effectively relieves tactile allodynia-associated neuropathic pain by targeting sensitization points stimulated by PIEZO2, a mechanosensitive ion channel. However, the molecular mechanisms underlying peripheral sensitization and...