Institution
Shanghai Innovative Research Center of Traditional Chinese Medicine
Recent research
- BiologyOpen access
Hyperactivation of the Wnt/β-catenin pathway is a key driver of epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) resistance in non-small cell lung cancer (NSCLC), with pyruvate kinase M2 (PKM2) serving as a critical transcriptional coactivator of β -catenin....
- Materials & EnergyOpen access
Pretrained 3D Molecular Representations Enable Data-Efficient Discovery of High-Energy-Density Fuels
High-energy-density hydrocarbon (HEDH) fuels are essential for aerospace propulsion, yet the design of such fuels is limited by the scarcity of reliable property data. In this work, we fine-tuned Uni-Mol, a pretrained three-dimensional (3D) molecular representation learning frame...
- Materials & Energy
ABSTRACT Atomically precise metal nanoclusters (metal NCs) provide ideal platforms for probing structure–performance relationship in electrochemical CO 2 reduction reaction (eCO 2 RR). However, how ligand hydrophobicity governs long‐term electrode stability at the molecular level...
- AI & ComputingOpen access
Toward brain-inspired intelligence: a review of photonic neuromorphic computing systems
Abstract Inspired by the key elements and principles in the brain, photonic neuromorphic computing shows great potential for building next-generation intelligent processing systems with high parallelism, low latency, low power consumption, and self-learning capabilities. While su...
- Health & MedicineOpen access
Gut–Brain–Skin Axis: From Mechanistic Insights to Translational Applications in Neurocosmetics
The gut–brain–skin axis is a proposed integrative framework describing interactions among the gastrointestinal tract, skin, and nervous system through neural, endocrine, immune, and microbial processes. Accumulating evidence has redefined the skin as a sophisticated neuro-immune-...
- BiologyOpen access
As a widely used anticoagulant, heparin is industrially produced chiefly via animal tissue extraction, which suffers from unstable supply and potential safety hazards. Heparosan shares a similar polysaccharide backbone with heparin and can be converted into heparin under mild enz...
- Materials & Energy
Abstract Barocaloric effects (BCE) represent an appealing refrigeration technology and have attracted great interest recently. However, most BCE materials still cannot meet real-world refrigeration requirements because of their fixed phase transition temperature TC and the signif...
- Biology
Defect Engineering of DNA Origami ROS Sensors for Portable Urinalysis
ABSTRACT Translating in situ dynamic changes of key signaling molecules into actionable clinical readouts remains a formidable challenge for noninvasive diagnostics. Here, focusing on reactive oxygen species (ROS) as pivotal signaling mediators, we developed defect‐programmed DNA...