Shanghai First Maternity and Infant Hospital

Photo‐Controlled Treatment for Psoriasis‐Like Skin Lesions by UVB‐Photoactivated Hydrogen Sulfide Donors and Pterostilbene

ABSTRACT Smart and efficient drug delivery is always desirable, especially for chronic diseases, such as psoriasis. We developed an ultraviolet B (UVB) light‐triggered scaffold, 1,4,2‐dioxazol‐5‐thione (DOT), for the controlled release of hydrogen sulfide (H 2 S), a pivotal endog...

Identification of Immune-Related Hub Genes as Candidate Biomarkers for Preeclampsia: Integrative Transcriptomic and Machine Learning Approaches

Abstract Preeclampsia (PE) is a major cause of maternal and perinatal morbidity and is increasingly recognized as a disorder involving immune dysregulation. However, reliable candidate biomarkers and key molecular alterations associated with PE remain unclear. We integrated multi...

Clinical outcomes after cystectomy or unilateral salpingo-oophorectomy for seromucinous borderline ovarian tumors: a single-center retrospective cohort study

Seromucinous borderline ovarian tumor (SMBT) is an uncommon subtype of borderline ovarian tumor characterized by Müllerian-type differentiation and frequent coexistence with endometriosis. Because of its rarity, its clinicopathological characteristics and the oncologic and reprod...

Effects of dural puncture epidural technique at different lumbar interspaces on labor analgesia: a randomized controlled trial

Dural puncture epidural (DPE) technique is increasingly used for labor analgesia, but evidence for optimal lumbar interspace selection remains limited. Although lumbar interspace selection has been reported to influence the onset of conventional epidural analgesia, whether a simi...

Single-nucleus transcriptomics reveals an early-relapse-associated epithelial–myeloid–T cell niche in advanced high-grade serous ovarian cancer

Early relapse remains a major clinical challenge in advanced HGSOC, but the tumor microenvironmental features associated with relapse timing remain poorly defined. Here, we performed snRNA-seq on treatment-naive tumors from patients with advanced HGSOC, including STDFS ( n = 4) a...

Prostaglandin E2-mediated aging microenvironment fuels pathogenic fibrosis in cesarean section scar defect

Abstract With the increasing rates of cesarean section (CS), cesarean section scar defect (CSD) has become an escalating clinical concern due to uterine dysfunction and reduced fertility. However, the biological basis of CSD remains poorly understood, particularly the mechanisms...

Between desire and constraint: reproductive intentions among working mothers in urban Shanghai—a qualitative study

Research on fertility intentions has largely focused on individual-level predictors such as income, education, and childcare burden, yet less attention has been paid to how these factors are embedded in and shaped by broader social systems. Drawing on in-depth interviews with 15...

Prophylactic administration of caffeine reduces bronchopulmonary dysplasia in very preterm infants: a single center, randomized controlled trial

Caffeine has been widely used to prevent apnea in very preterm infants (VPIs), but it is not clear whether prophylactic administration of caffeine can prevent bronchopulmonary dysplasia (BPD) in VPIs. This single-center, randomized clinical trial recruited very preterm neonates (...

Integrative analysis of the embryonic origin of adult neural stem cells in forebrain subventricular zones

Abstract In the mammalian brain, adult neural stem cells (NSCs) located in ventricular-subventricular zone (V-SVZ) of lateral ventricles and dentate gyrus continuously generate new neurons and glia throughout life. The adult NSCs in V-SVZ are derived from ventricular radial glial...

Association of prenatal noise exposure with postpartum depressive symptoms and self-harm ideation

Environmental noise is a pervasive but understudied determinant of perinatal mental health. We investigated whether prenatal residential noise exposure was associated with postpartum depressive symptoms and clinically documented self-harm ideation, thereby extending evidence beyo...

Label-free ovarian cancer histopathological diagnosis using two-photon autofluorescence microscopy with a joint denoising and segmentation framework

Two-photon autofluorescence (TPAF) microscopy is a promising modality for rapid, label-free assessment of unstained tissue, but is fundamentally limited by the poor visibility of nuclei, which are one of the gold-standard cancer biomarkers, due to their negative contrast nature....

Acox2 deficiency induces cardiac dysfunction via cross-organ metabolic reprogramming in mice

Abstract Background Secondary cardiomyopathies are a major cause of heart failure (HF) with diverse etiologies and high mortality rates. For example, over 50% of patients with end-stage liver disease develop cardiac dysfunction, clinically termed cirrhotic cardiomyopathy (CCM). W...

The influence of maternal complications on small for gestational age in very preterm, late preterm and term pregnancies: a Chinese study

This study aimed to assess the association between single or combined maternal complications and small-for-gestational-age (SGA) birth among very preterm, late preterm, and term births and to evaluate whether this association varied across gestational periods. This retrospective...

Metal‐Organic Framework‐Enabled Protection of Plasma DNA for Long‐Term Storage and Rare Mutation Detection

ABSTRACT Plasma DNA analysis remains a pivotal noninvasive approach for cancer diagnosis; however, the low abundance and rapid degradation of circulating tumor DNA (ctDNA) present significant challenges for sample preservation and transport. Existing stabilization methods often f...