Shanghai East Hospital

Lactate‐Induced K370 Lactylation of STING Inhibits STING‐TBK1 Signaling and Dampens Anti‐Tumor Immunity

ABSTRACT The stimulator of interferon genes (STING) pathway represents a central component of innate anti‐tumor immunity; however, the efficacy of STING‐targeted therapies is frequently limited by tumor‐intrinsic resistance mechanisms. Here, we identify lactate‐driven lactylation...

METTL3-mediated m6A modification of TP73-AS1 enhances HCC progression by activating Wnt/β-catenin signaling

Long noncoding RNAs (lncRNAs) play key roles in the onset and progression of hepatocellular carcinoma (HCC). Tumor protein 73 antisense RNA 1 (TP73-AS1), a recently identified lncRNA, has been implicated in cancer occurrence, drug resistance, and prognosis; however, its function...

Mefatinib versus gefitinib as a first-line treatment for EGFR-mutated non-small cell lung cancer: a randomized, double-blind, multicenter phase III study

Mefatinib, a novel second-generation epidermal growth factor (EGFR) tyrosine kinase inhibitor that has shown promising antitumor activity in targeting non-small cell lung cancer (NSCLC) with common and uncommon EGFR- activating mutations. In this phase III, randomized, double-bli...

Clinical utility of molecular residual disease detection in early-stage resected EGFR-mutated non-small cell lung cancer

Molecular residual disease (MRD), detected through circulating tumor DNA, has emerged as a promising biomarker for surveillance in patients with early-stage non-small cell lung cancer (NSCLC) following curative-intent resection. Here we report the MRD analysis from the phase 3 EV...

Targeting Mitochondrial Complex I Protects Against Palmitic Acid–Induced Endothelial Dysfunction

ABSTRACT Background Endothelial dysfunction induced by elevated free fatty acids is a critical initiating event in diabetic macrovascular complications. While mitochondrial reactive oxygen species (mtROS) are key mediators of this lipotoxic injury, the specific contribution of mi...

Challenges and Transformations in Biomedical Statistics Research Driven by Artificial Intelligence

ABSTRACT With the rapid advancement of artificial intelligence (AI) technology, the field of biomedical statistics has embraced novel solutions in areas such as data processing, variable control, and model formulation. This paper explores how AI technology is driving a transforma...

Layered double hydroxide-based ROS-scavenging nanozyme hydrogels re-establish osteoimmune-angiogenic coupling for osteoporotic bone repair

Abstract Background Osteoporotic bone defects (OP-BDs) present a significant clinical challenge because of a pathological microenvironment characterized by severe oxidative stress, persistent inflammation, and disrupted metabolic coupling between osteoblasts and osteoclasts. To o...

Structure-based design of peptide inhibitors targeting the SPSB2–iNOS interaction: a computational approach to modulating nitric oxide signaling

Dysregulation of inducible nitric oxide synthase (iNOS) plays a central role in inflammatory diseases, cancer, and neurodegeneration due to excessive nitric oxide (NO) production. Suppressor of Cytokine Signaling Box Protein 2 (SPSB2) is a key negative regulator of iNOS through s...