Shanghai East Hospital

Multimodal analysis of sleep disturbances and heart disease in older adults: a machine learning and exploratory path analysis approach

Sleep disturbances and heart disease are common among older adults, yet the psychological and functional pathways linking sleep symptoms to heart disease remain insufficiently characterized. This study examined the association between sleep disturbance indicators and heart diseas...

Rapid versus slow puncture in endoscopic ultrasound-guided liver biopsy: a multicenter randomized crossover trial

Abstract Endoscopic ultrasound-guided liver biopsy (EUS-LB) is increasingly used for hepatic histologic assessment; however, optimal technical approaches remain undefined. This prospective, multicenter clinical study aimed to compare tissue acquisition and safety between the rapi...

Clinical Outcome Differences in Asia Versus Non-Asia Intracerebral Hemorrhage: IPD Analysis From BP-Lowering Clinical Trials

BACKGROUND: Evidence of regional differences in clinical outcomes after intracerebral hemorrhage (ICH) is still scarce. We quantified differential outcomes and response to early intensive blood pressure lowering treatment by region in the Blood pressure in Acute Stroke Collaborat...

A Novel Reactive Oxygen Species‐Responsive Bone‐Targeted Nanoplatform Based on Cloperastine Attenuates Ovariectomy‐Induced Bone Loss by Inhibiting Osteoclast Oxidative Phosphorylation

ABSTRACT Postmenopausal osteoporosis is caused by excessive osteoclast‐mediated bone resorption. This study identifies mitochondrial oxidative phosphorylation (OXPHOS) as a tractable metabolic target for antiresorptive therapy. A literature‐guided drug repurposing screen focused...

From accuracy to applicability: A consensus-aligned narrative review on bedside ECG- and ultrasound-based PICC tip positioning

Peripherally inserted central catheter (PICC) tip positioning is a technically mature field characterized by heterogeneous evidence. International consensus guidelines consistently recommend bedside intracavitary electrocardiography (IC-ECG) and ultrasound-based strategies as fir...

Accelerometer-measured moderate-to-vigorous physical activity patterns and mortality among individuals with venous thromboembolism: a prospective cohort study from the UK Biobank

Although the “weekend warrior” activity pattern has been associated with lower mortality in the general population, whether it is associated with long-term outcomes after venous thromboembolism (VTE) remains unclear. In this prospective analysis, we examined the association betwe...

Combined femoral nerve block and posterior knee pain-point infiltration for early passive knee training after total knee arthroplasty: a two-center sham-controlled proof-of-concept randomized trial

Abstract Background We assessed whether a combined regional analgesic regimen administered immediately before passive knee training on postoperative day 3 was associated with active knee range of motion (ROM) 90 days after the intervention. Methods In this two-center, parallel-gr...

Primary tumor location and mortality in melanoma: Considerations for future staging systems

Wei et al. reported an association between primary tumor location (PTL) and mortality in patients with cutaneous malignant melanoma, highlighting a higher mortality risk for head and neck (HN) melanomas. Although these findings support the potential prognostic relevance of PTL, s...

FGF21 Pretreatment Promotes the Cardioprotective Effects of Mesenchymal Stem Cells in Myocardial Infarction via Enhancement of Their Survival and Paracrine Effects

Background: The poor engraftment of mesenchymal stem cells (MSCs) in the ischemic heart post transplantation heavily restricts their cardioprotective benefits in myocardial infarction (MI). Pretreatment has emerged as a novel approach to enhance the biological properties of MSCs...

Electrochemically Self‐Driven Interfacial Selenium Transfer Reshapes Sulfur Redox Pathway in Lithium–Sulfur Batteries

ABSTRACT Sulfur redox in lithium–sulfur (Li–S) batteries is governed by a multistep liquid–solid conversion network involving soluble polysulfide intermediates and continuously evolving solid–liquid interfaces. Here we identify an electrochemically self‐driven interfacial anion‐t...

Automated pancreatic segmentation and regional fat quantification suggest tail fat association with type 2 diabetes

Abstract Accurate pancreatic segmentation and quantitative assessment are crucial for investigating diabetes pathogenesis. Despite advancements in deep learning, regional segmentation remains challenging due to the organ’s anatomical complexity. This study established a two-stage...

Smart Implant Coating with Pathological-Microenvironment-Driven Drug and Nanozyme Delivery for Osteoporotic Bone Healing

Stimuli-responsive drug delivery from orthopedic implants holds particular promise for enhancing osseointegration in osteoporotic bone. However, challenges such as the lack of feedback-regulated functionality and microenvironmental modulation persist. Here, we developed an osteop...

A New Method for Optimizing Spinal Canal Cross-Sectional Area During Laminoplasty: Lateral Mass Gutter

Study Design Retrospective Cohort Study. Objective To propose a new technique named “lateral mass gutter” and investigate its role in augmenting spinal canal cross-sectional area (SCA) during laminoplasty. Methods This study included 105 patients who received cervical laminoplast...

HDAC4 drives ferroptosis and fibrosis by inhibiting Foxo3a-GPX4 axis during AKI–CKD progression

Abstract Histone deacetylase 4 (HDAC4) modifies both histone and non-histone proteins, but its role in the transition from acute kidney injury (AKI) to chronic kidney disease (CKD) remains unclear. Here, we investigated the function and mechanism of HDAC4 in ischemia–reperfusion...

Inhibition of Acetylation Activity of p300/ CBP Ameliorates Hepatic Steatosis Through Downregulation of ACSL4

BACKGROUND & AIMS: Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent chronic liver disorder, with few optimal pharmacotherapies. Ongoing studies are providing evidence that histone acetylation contributes to the progression of MASLD. This stud...

Anti-cancer drug clinical research

Abstract Malignant tumors are major diseases that seriously threaten human health, and the unmet clinical demand for treatments in the field of oncology has been persistently large. The research and development of new antineoplastic drugs has become a powerful means to address th...

PANoptosis-related HLTF promotes prostate cancer progression and serves as a potential therapeutic target

Accumulating evidence indicates that pan-apoptosis plays a significant role in tumour progression, highlighting the importance of determining its relevance to tumour prognosis and treatment. This study aims to classify the molecular patterns of pan-apoptosis and explore the molec...

Longitudinal spatial multi-omics delineates tumor microenvironment remodeling across sequential EGFR-TKIs in EGFR-mutant NSCLC

Abstract Background Resistance to therapy is a frequent occurrence in patients with epidermal growth factor receptor (EGFR)-mutant non-small-cell lung cancer (NSCLC) who are treated with EGFR tyrosine kinase inhibitors (EGFR-TKIs). However, spatial information on how the tumor mi...

Mechanism and experimental validation of a network pharmacology-based approach of Huoluo Yinao formula in treating chronic cerebral hypoperfusion.

experiments. The active ingredients and drug targets of HLYN formula obtained through network pharmacological analysis were subjected to molecular docking with disease targets of CCH. Wistar male rats (six weeks) were used to establish a CCH rat model by the two-vessel occlusion...

Role and diagnostic value of miR-3188 targeting OGT in regulating osteoblast function in delayed fracture healing of tibial fractures

This study investigated the role and mechanism of miR-3188 in delayed healing of tibial fractures, aiming to aid diagnosis and targeted intervention. A total of 172 patients with tibial fracture were enrolled and divided into normal fracture healing group (NFH, n = 82) and DFH (...