Shanghai Clinical Research Center

Recognition and mechanism of M. tuberculosis cell wall galactan transport

Mycobacterial-derived lipid-linked galactan (LLG) is an essential component of the Mycobacterial tuberculosis (Mtb) cell wall core arabinogalactan (AG), a well-established virulence factor and target of anti-tubercular drugs. Cross-membrane translocation of LLG is energetically u...

PLOD1 Catalytic Activity Stabilizes ENO1 by Limiting FBXW7‐dependent Degradation to Promote Glycolysis and TMZ Resistance in Glioblastoma

ABSTRACT Acquired resistance to temozolomide (TMZ) remains a major therapeutic challenge in glioblastoma (GBM), with metabolic reprogramming emerging as a critical driver of treatment failure. Procollagen lysyl hydroxylase 1 (PLOD1) is identified as a key regulator of adaptive me...

Myocardial tissue characteristics assessed by multiparametric CMR in hyperthyroid patients with suspected cardiac involvement

Abstract Background Hyperthyroidism is reportedly associated with increased cardiovascular risk and heart failure. However, a definite association between hyperthyroidism and cardiomyopathy has not been reported. This study aimed to analyze alterations in myocardial tissue charac...

Rotational stability and visual outcomes of toric implantable collamer lenses in eyes with horizontal and non-horizontal implanting orientation: an observational study

PURPOSE: To evaluate the short-term rotational stability and visual outcomes of the toric intraocular collamer lens (TICL) with horizontal and non-horizontal implantation orientation based on the Callisto eye system. METHODS: This observational study analyzed 77 eyes from 51 pati...

The effect of HIF-PHIs on anemia in non-dialysis-dependent CKD patients: a systematic review and network meta-analysis

This study compared the effects of hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHIs) and erythropoiesis-stimulating agents (ESAs) on anemia in non-dialysis-dependent chronic kidney disease (ND-CKD), with emphasis on follow-up duration and iron-metabolism markers....

Evaluation of FatNav‐Based Prospective Motion Correction for Perivascular Space Imaging With T2‐Weighted MRI at 7 T

ABSTRACT Subject motion during MRI acquisition is one of the major factors limiting image quality and diagnostic value. Previous studies have demonstrated the effectiveness of prospective motion correction (PMC) in mitigating motion‐related artifacts. However, the effectiveness o...

Carbon Dots as Versatile Nanoplatforms for Ophthalmic Therapeutics

Carbon dots (CDs), an emerging class of carbon-based nanomaterials, have attracted increasing interest in ophthalmology owing to their excellent biocompatibility, unique optical properties, tunable surface chemistry, and superior tissue penetration. These features render CDs high...

Multi-omics Mendelian randomization analysis prioritizes DNA methylation-related mitochondrial genes in congenital heart disease

Mitochondrial dysfunction has been increasingly recognized as a key pathophysiological contributor to congenital heart disease (CHD), yet its underlying genetic causal effects remain incompletely characterized. This study aimed to investigate the genetically supported association...

20-year experience of biomet stock alloplastic temporomandibular joint replacement in Chinese patients after technical modifications: a single-center retrospective study.

OBJECTIVES: To evaluate the clinical and radiographic outcomes of the Biomet stock alloplastic temporomandibular joint replacement (ATJR) after seven progressive surgical modifications in Chinese patients at a single center. MATERIALS AND METHODS: Patients who underwent ATJR from...

Microplastics in pediatric asthma: Clinical associations with disease severity

Background Respiratory exposure to microplastics (MPs) is increasingly recognized as a potential contributor to chronic airway disease, but the MPs burden in children with asthma and its relationship to disease remain poorly defined. Methods In this cross-sectional study, sputum...

Evaluationof 18F-FPPA as a PositronEmission Tomography Radioligand for Imaging CSF1R in LPS-Induced RatModel of Neuroinflammation

Abstract Noninvasive detection of microglia is crucial for monitoring their spatiotemporal dynamics and facilitating early medical intervention during the prodromal stages of these neuroinflammatory diseases. Colony-stimulating factor 1 receptor (CSF1R) is a promising imaging bio...