Shanghai Children's Medical Center

Haematological changes after tonsillectomy in mild thalassemia children recommendations

Objective This study aims to evaluate the alterations in peripheral blood parameters and the therapeutic outcomes following tonsillectomy in pediatric patients diagnosed with mild thalassemia. Methods We conducted a prospective cohort study involving 65 children who underwent ton...

The Longitudinal Association Between Shyness and Cognitive Biases Among Rural Chinese Children: A Three-Wave Cross-Lagged Analysis

This study investigated longitudinal relationships between shyness and three types of cognitive biases (i.e., probability judgment bias, cost judgment bias, and threatening interpretation bias) among rural Chinese children. A three-wave design (lasting 12-month) was employed with...

Clinical characteristics and influencing factors of children with MT-TL1 gene m.3243 A > G mutation: a phenotypic study based on 11 Han Chinese patients

The m.3243 A > G mutation in the MT-TL1 gene is one of the most common mitochondrial DNA variants, associated with a broad range of clinical phenotypes. While its manifestations in adults have been widely reported, data on pediatric presentations remain limited, particularly in A...

Clinical management and prognosis of tachycardia-induced cardiomyopathy in children: a retrospective cohort study with 15-year single-center experience

We described the clinical features and prognosis of pediatric tachycardia-induced cardiomyopathy (TIC). We retrospectively reviewed the data of children with TIC at a tertiary children’s hospital in China between 2009 and 2024. Overall, 101 children (58 boys) were included, with...

Common SAEs and their impact on the prognosis of children treated with the CCCG-ALL-2015 protocol: a retrospective multicentre Chinese study

This study was intended to evaluate common serious adverse events (SAEs) and analyze their effects on the prognosis of acute lymphoblastic leukemia (ALL) children. We retrospectively collected the data of 7640 consecutive ALL children with/ without SAEs who were enrolled in CCCG-...

m⁶A-dependent TRIM71 stabilization by YTHDC1 promotes hepatoblastoma progression

Abstract Hepatoblastoma (HB) is the most common primary malignant liver cancer in children. Although complete surgical resection and standardized chemotherapy remain the most effective treatments for HB, they are not curative for all patients. Therefore, a deeper understanding of...

Ceria-Based Nanotherapeutics for Inflammatory Skin Disorders: From Design and Mechanisms to Advanced Delivery and Future Perspectives

Inflammatory skin diseases, including atopic dermatitis (AD), psoriasis, diabetic wounds, and photoaging, represent major public health challenges due to their high prevalence, chronic recurrence, and substantial disease burden. Current treatments, such as glucocorticoids, calcin...

Platelet miRNAs for early diagnosis of Kawasaki disease: development and internal validation of a clinical model

Early diagnosis of Kawasaki disease (KD) remains challenging, particularly in incomplete or early-stage cases, increasing the risk of coronary artery complications. Platelet-derived microRNAs (miRNAs) are implicated in KD pathogenesis, but standardized normalization and validated...

Multi-omics Mendelian randomization analysis prioritizes DNA methylation-related mitochondrial genes in congenital heart disease

Mitochondrial dysfunction has been increasingly recognized as a key pathophysiological contributor to congenital heart disease (CHD), yet its underlying genetic causal effects remain incompletely characterized. This study aimed to investigate the genetically supported association...

Morphology‐Engineered Bismuth‐Porphyrin MOFs for H 2 S Scavenging Mediated Synergistic Photo‐Immunotherapy Against MRSA‐Infected Diabetic Wounds

ABSTRACT Diabetic wounds infected with methicillin‐resistant Staphylococcus aureus (MRSA) pose a significant challenge to clinical healing. Proliferating MRSA not only invades neutrophils to induce immunosuppression but also produces hydrogen sulfide (H 2 S) and forms biofilms to...

Do Normal Early Ultrasound Findings Predict Normal Acetabular Development? A Study of Late-Presenting Dysplasia in Graf Type I Hips

Background: Developmental dysplasia of the hip (DDH) is increasingly recognized as a dynamic condition that may evolve after birth. This study aims to evaluate the natural history of hips with normal or borderline findings on early ultrasound and to identify imaging features asso...

Neonatal Reversible Aortic Constriction Mice Model Unlocks Distinctive Footprints of Young Heart Recovery

BACKGROUND: Left ventricular (LV) reverse remodeling has been linked to long-term prognosis and life quality of pediatric patients with LV outflow tract obstruction. However, a lack of suitable animal model limits further study of LV reverse remodeling in young hearts. This study...

Association Between Vitamin D and Muscle Mass and Function in Children and Adolescents

OBJECTIVE: This study aimed to investigate the association between vitamin D and muscle health in children and adolescents. DESIGN: A cross-sectional analysis was performed using data from 2,775 participants aged 8-17 years in NHANES 2011-2014. Muscle mass was evaluated through w...

Digital therapeutics for mild adolescent idiopathic scoliosis: a protocol for a randomized controlled trial

Abstract Background Digital therapeutics (DTx), a new type of intervention presented in the last few years, can be used to provide patients with access to evidence-based therapeutic interventions using high-quality software programs to achieve the purpose of treating, managing, o...

Systemic metabolic remodeling in mucopolysaccharidosis revealed by untargeted urinary metabolomics

Abstract Background Mucopolysaccharidoses (MPS) are lysosomal storage disorders characterized by glycosaminoglycan (GAG) accumulation and progressive multi-organ dysfunction. However, the systemic metabolic consequences of lysosomal dysfunction remain incompletely defined. Method...