Shanghai Children's Hospital

Digital therapeutics for mild adolescent idiopathic scoliosis: a protocol for a randomized controlled trial

Abstract Background Digital therapeutics (DTx), a new type of intervention presented in the last few years, can be used to provide patients with access to evidence-based therapeutic interventions using high-quality software programs to achieve the purpose of treating, managing, o...

DUSP4 promotes anti-tumor CD8+ T cell function and boosts CAR-T cell efficacy in mouse colorectal cancer

The activation and function of CD8+ T cells, which are central for anti-tumor immunity, are tightly regulated by extracellular and intracellular signaling pathways. Dual-specificity phosphatases (DUSP), including DUSP4, dephosphorylate serine/threonine and tyrosine residues of pr...

Dentofacial Orthopedic Treatment vs. Adenotonsillectomy in Children with Mild to Moderate OSA and Mandibular Retrognathia: A Randomized Controlled Trial

Background/Objectives: Pediatric obstructive sleep apnea (OSA), particularly when accompanied by mandibular retrognathia, presents as a complex, multifactorial condition. Dentofacial orthopedic treatment (DOT) has gained increasing clinical attention; however, high-level evidence...

Macrophage-derived IL-1β drives endothelial-mesenchymal transition in diabetes mellitus erectile dysfunction

Diabetes mellitus erectile dysfunction (DMED) is frequently accompanied by corpus cavernosum (CC) fibrosis and endothelial dysfunction; however, the cellular drivers and molecular mechanisms underlying these pathological changes remain incompletely understood. Endothelial-to-mese...

Sodium Butyrate Attenuates Renal Fibrosis by Regulating Glycolysis and Histone H4K12 Lactylation in Diabetic Kidney Disease

ABSTRACT Background The role of histone lactylation in diabetes associated renal fibrosis remains poorly defined. In this study, we investigated the contribution of histone H4 lysine 12 lactylation (H4K12la) to abnormal glycolysis and renal fibrogenesis in diabetic kidney disease...

Multi-level static and dynamic graph-theoretical analyses of resting-state functional networks in a Chinese cohort of preterm neonates

Preterm birth influences early functional brain maturation at term-equivalent age. Using resting-state functional magnetic resonance imaging from a large Chinese neonatal cohort (62 term-born and 107 preterm neonates), we examined static and dynamic network organization using mul...