Shanghai Children's Hospital

Associations of long-term Tai Chi practice with vascular health in middle-aged and older adults: potential indirect roles of inflammation and oxidative stress - a cross-sectional study

Tai Chi is a widely practiced mind-body exercise, but its associations with vascular health and the potential involvement of inflammation and oxidative stress remain unclear. We hypothesized that, compared with irregular exercise, long-term Tai Chi practice would be associated wi...

Negotiated meaning-making under communicative constraints: professionals’ perspectives on paediatric palliative care in mainland China

Paediatric end-of-life care in mainland China occurs within contexts shaped by death taboo, protective silence, and the uneven development of palliative care services. Drawing on interviews with paediatric palliative care professionals, this qualitative study explored professiona...

Arterial‐Ventricular Coupling Strain Index as an Independent Predictor of 10‐Year ASCVD Risk in Diabetic‐Hypertensive Patients

BACKGROUND AND AIMS: The combination of diabetes mellitus and hypertension significantly increases the risk of cardiovascular diseases (CVD). This study aimed to evaluate the association between ventricular-arterial coupling and the 10-year atherosclerotic cardiovascular disease...

Clinical phenotypic and genotypic analysis of Gitelman syndrome in children

Gitelman syndrome (GS) is a rare autosomal recessive tubulopathy caused by SLC12A3 variants, leading to hypokalemic metabolic alkalosis and other electrolyte disturbances. This study aimed to investigate the genotype and clinical phenotype in pediatric patients with GS. This stud...

Circumcision and continuous antibiotic prophylaxis in preventing recurrent febrile urinary tract infection in boys with high-grade vesicoureteral reflux

OBJECTIVE: To evaluate the effectiveness of circumcision and continuous antibiotic prophylaxis (CAP) in preventing febrile urinary tract infection (fUTI) in boys with high-grade primary vesicoureteral reflux (VUR). METHODS: This retrospective cohort included 114 boys younger than...

Common SAEs and their impact on the prognosis of children treated with the CCCG-ALL-2015 protocol: a retrospective multicentre Chinese study

This study was intended to evaluate common serious adverse events (SAEs) and analyze their effects on the prognosis of acute lymphoblastic leukemia (ALL) children. We retrospectively collected the data of 7640 consecutive ALL children with/ without SAEs who were enrolled in CCCG-...

m⁶A-dependent TRIM71 stabilization by YTHDC1 promotes hepatoblastoma progression

Abstract Hepatoblastoma (HB) is the most common primary malignant liver cancer in children. Although complete surgical resection and standardized chemotherapy remain the most effective treatments for HB, they are not curative for all patients. Therefore, a deeper understanding of...

Platelet miRNAs for early diagnosis of Kawasaki disease: development and internal validation of a clinical model

Early diagnosis of Kawasaki disease (KD) remains challenging, particularly in incomplete or early-stage cases, increasing the risk of coronary artery complications. Platelet-derived microRNAs (miRNAs) are implicated in KD pathogenesis, but standardized normalization and validated...

AR/PARP Dual‐Targeting Bioactive Photosensitizer for Photo‐Immunotherapy of Prostate Cancer

Prostate cancer poses a severe threat to men's health worldwide, and conventional therapeutic modalities are associated with various limitations. Photodynamic therapy (PDT) offers distinctive advantages such as minimal invasiveness, mild side effects and repeatable treatment. How...

Mapping the senescent stromal landscape and altered the immune microenvironment in PCOS endometrium

Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder affecting approximately 10% of reproductive-aged women and is a major cause of infertility. Inadequate endometrial receptivity is a pivotal contributor to this infertility, but its underlying cellular mechanisms r...

DUSP4 promotes anti-tumor CD8+ T cell function and boosts CAR-T cell efficacy in mouse colorectal cancer

The activation and function of CD8+ T cells, which are central for anti-tumor immunity, are tightly regulated by extracellular and intracellular signaling pathways. Dual-specificity phosphatases (DUSP), including DUSP4, dephosphorylate serine/threonine and tyrosine residues of pr...

Digital therapeutics for mild adolescent idiopathic scoliosis: a protocol for a randomized controlled trial

Abstract Background Digital therapeutics (DTx), a new type of intervention presented in the last few years, can be used to provide patients with access to evidence-based therapeutic interventions using high-quality software programs to achieve the purpose of treating, managing, o...

Dentofacial Orthopedic Treatment vs. Adenotonsillectomy in Children with Mild to Moderate OSA and Mandibular Retrognathia: A Randomized Controlled Trial

Background/Objectives: Pediatric obstructive sleep apnea (OSA), particularly when accompanied by mandibular retrognathia, presents as a complex, multifactorial condition. Dentofacial orthopedic treatment (DOT) has gained increasing clinical attention; however, high-level evidence...

Macrophage-derived IL-1β drives endothelial-mesenchymal transition in diabetes mellitus erectile dysfunction

Diabetes mellitus erectile dysfunction (DMED) is frequently accompanied by corpus cavernosum (CC) fibrosis and endothelial dysfunction; however, the cellular drivers and molecular mechanisms underlying these pathological changes remain incompletely understood. Endothelial-to-mese...

Sodium Butyrate Attenuates Renal Fibrosis by Regulating Glycolysis and Histone H4K12 Lactylation in Diabetic Kidney Disease

ABSTRACT Background The role of histone lactylation in diabetes associated renal fibrosis remains poorly defined. In this study, we investigated the contribution of histone H4 lysine 12 lactylation (H4K12la) to abnormal glycolysis and renal fibrogenesis in diabetic kidney disease...

Multi-level static and dynamic graph-theoretical analyses of resting-state functional networks in a Chinese cohort of preterm neonates

Preterm birth influences early functional brain maturation at term-equivalent age. Using resting-state functional magnetic resonance imaging from a large Chinese neonatal cohort (62 term-born and 107 preterm neonates), we examined static and dynamic network organization using mul...