Shanghai Chest Hospital

ENOPH1 orchestrates KRASG12D/G13D-driven glycolytic reprogramming and colorectal cancer progression through modulating the TGF-β/SMAD pathway

Oncogenic KRAS mutations (G12D/G13D) drive metabolic reprogramming in colorectal cancer (CRC), yet targetable downstream effectors remain poorly defined. Here, we identify enolase-phosphatase 1 (ENOPH1) as an essential transducer directly upregulated by the KRAS–MEK–ERK axis. ENO...

Circulating miR-106b-5p discriminates acute myocardial infarction patients, predicts disease severity, and regulates H/R-induced cardiomyocyte injury by targeting CDKN1A

The early detection, disease monitoring, and prognosis prediction are of great significance for acute myocardial infarction (AMI). This study focused on miR-106b-5p, evaluating its clinical significance in AMI onset and progression. This study enrolled 147 AMI patients with 123 s...

Transcriptomic analyses identify TMPRSS4 as a shared biomarker in asthma and atopic dermatitis

Asthma and atopic dermatitis (AD) are common chronic inflammatory diseases that often co-occur, but the underlying shared biological mechanisms remain elusive. In this study, we performed WGCNA analyses on GSE6012 and GSE67472 datasets and identified 24 genes associated with both...

Effects of cryo-parameters and retrieval methods on specimen acquisition and quality for ultrathin cryoprobe transbronchial cryobiopsy in porcine models

Ultrathin cryoprobes enable direct retraction through the working channel during transbronchial cryobiopsy. However, key factors of biopsy performance remain insufficiently characterized. This study evaluates cryo-parameters and retrieval methods across different working channels...

A Cross-Sectional Study of Short-Video Viewing and Young Adult Health: Dose–Response Relationships with Sleep, Dream Anxiety, Ocular Surface, and Quality of Life

Background: Short-video platforms (e.g., Douyin, TikTok) have gained immense popularity among young adults, yet their addictive potential and health consequences remain understudied. Unlike gaming addiction, which has been linked to myopia and mental distress, short-video viewing...

P1.185. Health-Related Quality of Life After Robot-Assisted Versus Thoracoscopic Esophagectomy: A Secondary Analysis From the Multicenter RAMIE Trial

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer Background The comparative effects of robot-assisted and thoracoscopic esophagectomy on postoperative health-related quality of life (HRQOL) are not well defined. Here, we sought to assess patient-reported...

P1.220. Totally Versus Hybrid Robot-Assisted Minimally Invasive Esophagectomy for Thoracic Esophageal Cancer: Similar Perioperative Safety and Oncologic Survival

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – early outcomes and complications Background This study compared the perioperative safety, quality of life and oncologic outcomes of the totally robot-assisted minimally invasive esophagectomy (ToRaMIE) te...

P1.155. Impact of Lymphaticvessel Invasion on Prognosis in Patients With Esophageal Squamous Cell Carcinoma Undergoing Neoadjuvant Immunochemotherapy: A Multicenter Retrospective Study

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer Background Prognostic stratification remains inadequate in patients with locally advanced esophageal squamous cell carcinoma (ESCC) following neoadjuvant immunotherapy combined with chemotherapy (NICT). Thi...

OA03-RF01.01. Patterns and Predictors of Recurrence in Patients With Esophageal Cancer Who Achieve Pathological Complete Response to Multimodal Therapy

Abstract Topic Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies Background Neoadjuvant chemoradiotherapy (nCRT) and chemoimmunotherapy (nICT) are increasingly used for locally advanced esophageal squamous cell carcinoma. Although pathological complete response (pCR) is asso...

Waist-to-height ratio as the optimal predictor of non-alcoholic fatty liver disease among medical staff: a cross-sectional study

This study aimed to assess the health of medical staff via body composition analysis, examine associations between anthropometric indices and NAFLD, evaluate their predictive value for NAFLD, and compare their performance in identifying NAFLD. A total of 622 medical staff in the...

DDX3x Regulates NINJ1 Transcription via Histone Lactylation in Sepsis Associated‐Acute Kidney Injury

Sepsis associated-acute kidney injury (SA-AKI), a severe complication of sepsis, is characterized by impaired tubular injury that can ultimately cause renal failure and patient mortality. Both histone and non-histone lactylation and cellular PANoptosis have been implicated in the...

Time‐Resolved Upconversion Lifetime Sensing for Selective Blood L‐Lactate Analysis During Postoperative Analgesia

Accurate and robust quantification of metabolic biomarkers in complex biological matrices is essential for understanding physiological responses during postoperative analgesia. Herein, we report a time‐resolved upconversion luminescence lifetime sensing platform for selective det...

Sodium Butyrate Attenuates Renal Fibrosis by Regulating Glycolysis and Histone H4K12 Lactylation in Diabetic Kidney Disease

ABSTRACT Background The role of histone lactylation in diabetes associated renal fibrosis remains poorly defined. In this study, we investigated the contribution of histone H4 lysine 12 lactylation (H4K12la) to abnormal glycolysis and renal fibrogenesis in diabetic kidney disease...