Shanghai Changzheng Hospital

Active Blood Cell Capture and Synergistic Coassembly: Self-Gelling Gelatin-Polysaccharide Powders for Rapid Hemostasis

While effective for irregular wounds, traditional hemostatic powders often lack posthydration cross-linking, yielding fragile barriers susceptible to washout under high-pressure hemorrhage. To address this, a novel self-gelling composite powder (GOQL) was developed by incorporati...

Comparative corneal biomechanical characteristics in polypoidal choroidal vasculopathy and neovascular age-related macular degeneration analyzed by corvis ST: a cross-sectional study

To explore the differences in corneal biomechanical characteristics among patients with polypoidal choroidal vasculopathy (PCV), neovascular age-related macular degeneration (nAMD), and healthy individuals. This cross-sectional study included patients with nAMD or PCV and healthy...

Reprogramming NOX4-associated ferro-aging with an iron-chelating senescent-cell-targeted therapy for intervertebral disc degeneration

Intervertebral disc degeneration (IVDD) has been a major contributor to chronic low back pain, yet effective disease-modifying therapies remain limited. Here, we identified a NOX4-associated ferro-aging program linking iron overload, oxidative stress, lipid peroxidation, and cell...

FGF-23 is associated with increased risk of abdominal aortic calcification

Fibroblast growth factor 23 (FGF23) is involved in the regulation of phosphate metabolism and has been linked to vascular calcification. However, the genetic association between FGF23 and abdominal aortic calcification (AAC) remains unclear. We conducted a bidirectional two-sampl...

Bile acid signaling in health and disease

Abstract Bile acids (BAs), cholesterol-derived amphipathic metabolites which are traditionally regarded as digestive surfactants, are now recognized as pleiotropic signaling molecules that act through ligand-, receptor-, and tissue-specific mechanisms to maintain systemic homeost...

Metabolic-epigenetic nanoregulator attenuates a folate-deficiency-associated senescence phenotype in intervertebral disc degeneration

Intervertebral disc degeneration (IVDD) is increasingly recognized as an aging-associated disorder driven in part by nucleus pulposus cell (NPC) senescence, yet the nutrient-sensitive metabolic defects that sustain this state remain poorly understood. Here, we investigated impair...

Development and validation of MRI-based radiomics models for predicting recurrence in patients with spine and pelvis chordomas

Spine and pelvis chordoma (SPC) is a rare and aggressive mesenchymal tumor with poor long-term recurrence-free survival rates. Accurate preoperative prediction of recurrence remains a significant clinical challenge, and reliable prognostic methods are lacking. To develop and vali...

Extrachromosomal DNA as a platform for epigenetic reprogramming in cancer

Extrachromosomal DNA (ecDNA) has emerged as a major contributor to cancer aggressiveness, yet its role extends far beyond its classical definition as a vehicle for oncogene amplification. Recent studies indicate that ecDNA functions as a dynamic regulatory platform that reshapes...

Definitional and interpretive challenges in rebound pain prevention

We read with interest the network meta-analysis by Singh et al. on prophylactic interventions for rebound pain after peripheral nerve block [1]. Their analysis of 24 randomised, controlled trials involving 2130 patients addresses an important clinical question, but some features...

Smart Implant Coating with Pathological-Microenvironment-Driven Drug and Nanozyme Delivery for Osteoporotic Bone Healing

Stimuli-responsive drug delivery from orthopedic implants holds particular promise for enhancing osseointegration in osteoporotic bone. However, challenges such as the lack of feedback-regulated functionality and microenvironmental modulation persist. Here, we developed an osteop...

Clinical characteristics and risk factors of recurrence for Pseudomonas aeruginosa -associated fracture-related infection following surgical treatment

Aims Pseudomonas aeruginosa (PA), a prevalent Gram-negative pathogen in fracture-related infections (FRIs), presents huge therapeutic challenges due to biofilm formation and multidrug resistance (MDR). Evidence-based guidelines for PA-associated FRI (PA-FRI) remain limited. The a...

Inhibition of Acetylation Activity of p300/ CBP Ameliorates Hepatic Steatosis Through Downregulation of ACSL4

BACKGROUND & AIMS: Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent chronic liver disorder, with few optimal pharmacotherapies. Ongoing studies are providing evidence that histone acetylation contributes to the progression of MASLD. This stud...

Vitamin D for type 2 diabetes prevention: cost-effective, but not yet cost-saving

Briody and colleagues provide the first cost-effectiveness analysis of vitamin D for preventing type 2 diabetes in US adults with prediabetes, addressing a gap identified by the 2024 Endocrine Society guideline.1 The microsimulation is careful and transparent, and the conclusion...

Acute Kidney Injury During Vancomycin Treatment in Adult Patients With Haematologic Malignancies: A Multicentre Retrospective Study

ABSTRACT Background Acute kidney injury (AKI) during vancomycin treatment remains a rare occurrence in adult patients with haematological malignancies (HMs). The objective of this multicentre study was to investigate the incidence and risk factors for AKI during vancomycin treatm...

Effect of SEEKflex-guided versus conventional intubation on hemodynamic responses in elderly hypertensive patients: a randomized controlled trial

In elderly patients with preexisting cardiovascular and cerebrovascular diseases, laryngoscopy and tracheal intubation can provoke substantial hemodynamic disturbances, including hypertension and tachycardia, which may precipitate major cardiovascular or cerebrovascular events an...

Development of a treatment classification system and treatment strategy for ligamentous ossification disease-traditional and innovative surgical strategies

Ligamentous ossification diseases like OPLL and OLF can cause severe neurological compromise. While whole-spine CT identifies ossified segments and MRI reveals cord compression/signal changes, treatment guidelines—especially for multi-level involvement—remain undefined, particula...