Shanghai Center for Brain Science and Brain-Inspired Technology

Dendritic computation for abstract rule-based flexible decision-making

Intelligent behavior involves flexible integration of sensory input and abstract rule knowledge. Dendritic computation has been shown to contribute to top-down modulation of sensory processing; however, whether and how it is involved in flexible cognitive processing remains to be...

Clinical Outcome Differences in Asia Versus Non-Asia Intracerebral Hemorrhage: IPD Analysis From BP-Lowering Clinical Trials

BACKGROUND: Evidence of regional differences in clinical outcomes after intracerebral hemorrhage (ICH) is still scarce. We quantified differential outcomes and response to early intensive blood pressure lowering treatment by region in the Blood pressure in Acute Stroke Collaborat...

Analytical Prediction of Critical Transitions in Oscillator Networks With Non‐Local Links

ABSTRACT A wide range of dynamical systems can be modeled as oscillators coupled through an interaction network. Such frameworks have been widely used to explore the emergence of collective phenomena across diverse applications. Here, we develop an analytical framework for oscill...

Prehospital Stroke Treatment Trials in Conventional EMS Settings: An Expert Consensus Statement on Operational, Ethical, and Technological Priorities

Prehospital stroke trials enable assessments of ultraearly administration of treatments and management strategies, but face unique challenges in their design, conduct, and analysis. We outline important considerations and recommendations for planning prehospital stroke trials, fo...

Physical Reservoir Computing with Optoelectronic Memristors for Event-Camera

Abstract The asynchronous and sparse event streams output by event cameras pose a significant challenge to traditional computing architectures, whereas physical reservoir computing (RC) systems based on optoelectronic memristors offer an effective solution for realizing efficient...

β‐ TP For Diagnosing CSF Leak After the Endoscopic Endonasal Approach Surgery for Sellar Tumors

ABSTRACT Objectives This study aimed to evaluate the diagnostic utility of quantitative beta‐trace protein (β‐TP) as an early biomarker for identifying postoperative cerebrospinal fluid (CSF) leaks following endoscopic endonasal approach (EEA) surgery for sellar tumors. Methods A...

Cognitive function among COVID-19 survivors in the subacute phase during the epidemic of Omicron variant in China

Following the relaxation of pandemic control measures in China, the impact of coronavirus disease 2019 (COVID-19) on cognitive function in the Chinese population has not been investigated. Therefore, this study aimed to assess cognitive function and identify its risk factors in t...

Learning stochastic dynamics and cell-fate landscapes from single-cell snapshots via optimal transport

The temporal dynamics and stochasticity of gene expression are critical to cell fate decisions, yet integrating snapshot omics data across multiple time points remains a major challenge. Here, we introduce DiffusionOT, a dynamic machine learning framework that infers cellular tra...

Spatial transcriptional signatures linked to brain activity patterns in MECP2 transgenic monkeys and human autism spectrum disorder

Imaging transcriptomics studies in autism spectrum disorder (ASD) have identified relevant biological pathways, yet the specific laminar molecular signatures associated with functional abnormalities remain largely unexplored. We integrated resting-state fMRI (rs-fMRI) data from m...

Reproducible human reward imaging phenotypes exhibit differential sensitivity to dopamine D2 receptor antagonism

Abstract Human reward processing varies along cue-centric and outcome-centric axes, but a reproducible mechanistic account of individual variation in incentive salience attribution has been lacking. Using fMRI across five cohorts (N-total=1,251; N1=890; N2=245; N3=34; N4=48; N5=3...

Galectin-3 worsens microglia-mediated synaptic engulfment and neuroinflammatory responses after traumatic brain injury

Activated microglia-mediated aberrant synaptic phagocytosis is an important contributor to neurological deficits following traumatic brain injury (TBI). Galectin-3 (Gal-3), a pivotal regulator of microglial activity, is increased after TBI. However, its role in microglia-mediated...

Exploring the medical road for implantable brain-computer interfaces

This article explores medical implantable brain-computer interfaces that prioritize neural restoration, with functional substitution as a complementary strategy to address both underlying dysfunction and functional deficits.

Time‐Resolved Upconversion Lifetime Sensing for Selective Blood L‐Lactate Analysis During Postoperative Analgesia

Accurate and robust quantification of metabolic biomarkers in complex biological matrices is essential for understanding physiological responses during postoperative analgesia. Herein, we report a time‐resolved upconversion luminescence lifetime sensing platform for selective det...

Adenosine 2A receptor drives microglial efferocytosis to accelerate white matter repair and functional recovery after stroke

Although reperfusion therapy effectively restores blood flow to occluded brain arteries after ischemic stroke, many patients develop persistent white matter injury, a major contributor to long-term neurological disability. Currently, there are few approved clinical therapies that...