Institution
Shanghai Cancer Institute
Recent research
- BiologyOpen access
ABSTRACT Lung adenocarcinoma (LUAD) remains a leading cause of cancer‐related mortality. Integrative multi‐omics and machine‐learning analyses across independent cohorts identified CYYR1 as a frequently downregulated transmembrane protein in LUAD, with low expression associated w...
- BiologyOpen access
ABSTRACT Limited aqueous dispersibility and potential off‐target toxicity hinder the development and clinical translation of proteolysis‐targeting chimeras (PROTACs). Herein, a bioactive self‐delivering “Split Nano‐Assembly of Photosensitizers and Targeting Chimeras” (SNAP‐TAC) t...
- Health & MedicineOpen access
Abstract This prospective, randomized, single-blinded, phase II trial evaluated whether large language model (LLM)-assisted preoperative communication, compared with standard communication, reduces patient anxiety and improves illness perception and satisfaction while decreasing...
- Health & Medicine
Disparities in Cancer Incidence by Sex and Associated Lifestyle Factors and Health Conditions
Importance Cancer risk is higher in males than females globally. Whether this sex disparity reflects a biological inevitability or is potentially modifiable by lifestyle behaviors and health conditions across diverse populations remains unclear. Objective To determine the contrib...
- Health & MedicineOpen access
Association between serum cotinine levels and prostate-related clinical endpoints
Abstract Purpose This study examined the association between serum cotinine, an objective biomarker of tobacco exposure, and prostate-related clinical endpoints in men participating in the National Health and Nutrition Examination Survey. Methods Cross-sectional data from five NH...
- BiologyOpen access
Urinary extracellular vesicles (uEVs) have emerged as promising non-invasive molecular carriers for biomarker discovery, yet the physiological variability and tissue-associated characteristics of uEV RNA cargo in healthy individuals remain poorly defined. This knowledge gap limit...
- BiologyOpen access
Deubiquitination of Vangl by USP6 and USP32 Regulates Planar Cell Polarity Signaling
ABSTRACT Planar cell polarity (PCP) signaling is an evolutionarily conserved mechanism regulating polarized cellular and tissue behaviors in diverse morphogenetic and physiological processes. Disruption or aberrant activation of PCP signaling can cause developmental defects or pr...
- Health & MedicineOpen access
Postoperative blood glucose levels: A predictor of poor survival in resected pancreatic cancer
Abstract Background: Although pancreatic resection influences glucose metabolism, the clinical impact of postoperative fasting blood glucose (FBG) on survival outcomes in patients undergoing curative-intent resection for pancreatic cancer remains unreported. Methods: Data from pa...
- Biology
Tissue engineering scaffolds for the spinal cord: recent advances and future prospects
Spinal cord tissue engineering scaffolds represent a highly promising option for the treatment and repair of spinal cord injury (SCI). They have a wide range of potential applications and, as essential biomaterial carriers, can restore the multifunctional microenvironment. Since...
- AI & ComputingOpen access
Head and neck squamous cell carcinoma (HNSCC) remains a major global health burden with limited targeted therapeutic options. Here we present an integrated artificial intelligence (AI)-driven drug discovery framework combining graph neural networks (GAT, GCN, AttentiveFP and GIN)...
- BiologyOpen access
Abstract Dysregulation of the ubiquitin-proteasome system (UPS) plays a pivotal role in tumor progression. PSMD11, a non-ATPase regulatory subunit of the 26S proteasome, has been implicated as an oncogenic factor in several cancer types; however, its precise biological function a...