Shanghai Blood Center

The effect of HIF-PHIs on anemia in non-dialysis-dependent CKD patients: a systematic review and network meta-analysis

This study compared the effects of hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHIs) and erythropoiesis-stimulating agents (ESAs) on anemia in non-dialysis-dependent chronic kidney disease (ND-CKD), with emphasis on follow-up duration and iron-metabolism markers....

Lactate drives maladaptive metabolic reprogramming via MRS2 in ischemia/reperfusion-induced acute kidney injury

Ischemia/reperfusion (I/R) triggers profound bioenergetic collapse in renal proximal tubular epithelial cells (PTECs), inducing acute kidney injury (AKI) and forcing a sustained shift from mitochondrial oxidative metabolism to glycolysis. Lactate accumulation is a hallmark of thi...

Deubiquitinase USP7 stabilizes the histone demethylase KDM5B and promotes the progression of renal fibrosis through the TSC1/mTOR axis

Abstract Ubiquitin-specific protease 7 (USP7) is a deubiquitinase that plays critical regulatory roles in multiple signaling pathways by preventing the ubiquitin-mediated degradation of its substrates. Dysregulated expression of USP7 is implicated in tumor progression; however, i...