Shandong University of Traditional Chinese Medicine

Gamma-Glutamyl Transferase and Cognitive Outcomes: A Cross-Species Analysis and Hepatic Transcriptomic Signature

Cognitive impairment is a major public health concern, and the liver–brain axis has attracted growing interest. Gamma-glutamyl transferase (GGT) is a serum marker of liver function, but its association with cognitive outcomes remains uncertain. We conducted a cross-species analys...

Single-cell transcriptomics and machine learning characterize LTA4H-linked lipid metabolism and inflammatory signatures in the knee osteoarthritis IPFP/synovium compartment

Knee osteoarthritis (KOA) is a whole-joint disease characterized by inflammation, immune dysregulation, and metabolic imbalance. To define lipid metabolism-related transcriptional heterogeneity within the infrapatellar fat pad (IPFP)/synovium compartment, we integrated publicly a...

Enhancing Natural Product Therapy with PROTACs: Targeted Degradation of TLR4 Confers Potent Endothelial Protection

Abstract TLR4-MyD88-mediated endothelial dysfunction drives cardiovascular disease. To overcome the weak efficacy of ferulic acid, we synthesized six ferulic acid-based PROTAC derivatives. Migration and TLR4 expression assays in HUVECs identified FP-4 as lead. FP-4 induced the ta...

Direct oral anticoagulants versus vitamin K antagonists in cirrhotic portal vein thrombosis: a systematic review and meta-analysis of clinical, radiological, and safety outcomes

The optimal anticoagulant strategy for portal vein thrombosis (PVT) in patients with cirrhosis remains uncertain. This systematic review and meta-analysis compared the clinical, radiological, and safety outcomes associated with direct oral anticoagulants (DOACs) versus vitamin K...

Gastric cancer burden from 1990 to 2021, Joinpoint analysis, projections to 2036, and health inequality assessment

Gastric cancer (GC) remains a major global health issue with high incidence and mortality. This study evaluates the global burden and health disparities of GC from 1990 to 2021 and projects trends through 2036, providing evidence for targeted control measures. The data were sourc...

From baseline levels to cumulative exposure and longitudinal trajectories: estimated glucose disposal rate and incident cardiometabolic multimorbidity among middle-aged and older adults in the English Longitudinal Study of Ageing (ELSA) and the Health and Retirement Study (HRS)

Abstract Background Insulin resistance is implicated in the development of cardiometabolic multimorbidity (CMM), but evidence regarding the associations of baseline, cumulative, and longitudinal patterns of estimated glucose disposal rate (eGDR) with incident CMM remains limited....

Predictors of clinical pregnancy after IVF in women with ovarian endometriomas: a propensity score-matched retrospective cohort study

Abstract Background Ovarian endometrioma (OMA) is associated with reduced in vitro fertilization (IVF) success rates. Therefore, the purpose of the study is to investigate risk factors associated with pregnancy outcomes following IVF in women with OMA and assess the predictive ut...

Defect-Engineered Core–Shell MOF Nanointerface Functionalized with Hemagglutinin for Target-Guided Anti-influenza Ligand Discovery

Abstract Preserving the biological function of conformationally dynamic proteins after immobilization remains a major challenge in biointerface engineering. Here, a defect-engineered hierarchical MOF nanointerface (D-MOF-808-HET@MOF-808@SiO2) was constructed through evaporation-i...

Platelet‐rich plasma exhibits antibacterial and anti‐inflammatory effects in an in vitro donkey endometritis model

Abstract Background Infectious endometritis, mainly caused by Escherichia coli ( E. coli ) and Streptococcus equi subsp. zooepidemicus ( SEZ ), significantly impairs donkey reproductive performance. Platelet‐rich plasma (PRP) shows promise as an anti‐inflammatory and antibiotic a...

A Collective CRISPR-Cas12a Biosensing Platform for Effect-Based Screening of Pesticide Residues

The simultaneous screening of multicomponent pesticide residues, rather than a single specific compound, remains a critical yet challenging frontier in safety surveillance, largely due to the inherent one-to-one recognition bottleneck in conventional aptamer- or antibody-based bi...

Berberine attenuates diabetic kidney injury via FOXO1/SP1-associated regulation of renal SGLT-2 expression

Abstract Background Berberine (BBR), a plant-derived isoquinoline alkaloid, has been reported to exert anti-hyperglycemic and renoprotective effects. However, the mechanism by which BBR regulates renal glucose transport under diabetic conditions remains unclear. Sodium-glucose co...

Salvianolic Acid a Disrupts the HSP90α‐AKT‐PERK Ternary Complex to Alleviate Atherosclerosis by Activating Endoplasmic Reticulum Stress of Senescent Vascular Smooth Muscle Cells

ABSTRACT Atherosclerosis is a chronic inflammatory disease driven by senescent vascular smooth muscle cells (VSMCs). Salvianolic acid A (SAA) exhibits cardiovascular protective effects; however, its role in atherosclerosis remains unclear. This study aimed to investigate the effe...

Exploring causal relationships between circulating inflammatory proteins and superficial thrombophlebitis

This study explores the potential causal relationship between circulating inflammatory proteins and superficial thrombophlebitis (STP) using Mendelian randomization (MR). We utilized data on 91 circulating inflammatory proteins from publicly available genome-wide association stud...

Acupuncture Alleviates Allergic Rhinitis by Activating the AMPK / PGC ‐1α Pathway to Attenuate Mitochondrial Oxidative Stress and Restore Epithelial Barrier Function

ABSTRACT This study aims to elucidate the molecular mechanisms underlying the therapeutic effects of acupuncture in allergic rhinitis (AR), with a focus on its mechanistic pathways. Experimentally, an ovalbumin (OVA)‐induced AR mouse model was established to evaluate the frequenc...

Dietary patterns and depression: a comprehensive review of associations, moderating factors, and underlying mechanisms

Depression is a widespread and multifaceted mental health disorder, shaped by genetic susceptibility, neurobiological dysfunction, and environmental stressors, which pose challenges for effective treatment. Emerging evidence suggests that diet plays a significant role in the occu...

Solubility Behavior of Baloxavir Marboxil in 13 Pure Solvents: Combined Experimental Measurement and Molecular Simulation Analysis

Abstract This study was designed to determine the solubility of Baloxavir marboxil (BXM) in 13 solvents (i.e., water, methanol, ethanol, n-propanol, i-propanol, i-butanol, s-butanol, n-pentanol, i-pentanol, acetone, ethyl formate, ethyl acetate, pentyl acetate) by high-performanc...

An Integrated Strategy for Decoding Bioactive Components and Mechanism of Jingtong Granules: Chemical Characterization, Network Analysis, Pharmacokinetic and Pharmacodynamic Studies

This study aimed to identify bioactive constituents of Jingtong Granules (JTG), a traditional Chinese medicine for cervical spondylotic radiculopathy (CSR), characterize their in vivo exposure, and explore pharmacological targets and pathways. Chemical constituents were character...

Prediction of low oocyte retrieval in young women undergoing IVF/ICSI: a multicenter external validation study

Abstract Objective To externally validate a previously developed pretreatment prediction nomogram for identifying young women at risk of low oocyte retrieval (LOR). Methods This multicenter retrospective study included 14,702 women aged ≤ 35 years undergoing their first in vitro...

Multilevel Mechanisms and Clinical Efficacy of Psilocybin in Depression Treatment: A Systematic Review

Depression, characterized by persistent low mood and anhedonia, represents a prevalent affective disorder imposing substantial medical and economic burdens. Current first-line antidepressants are limited by delayed onset and treatment resistance. Psilocybin (PSI) has re-emerged a...

Adjuvant lenvatinib plus transarterial chemoembolization is associated with better outcomes than gemcitabine plus cisplatin in combined hepatocellular cholangiocarcinoma

To evaluate and compare the efficacy and safety of lenvatinib combined with transarterial chemoembolization (TACE) and gemcitabine plus cisplatin (GP) as adjuvant treatments for combined hepatocellular-cholangiocarcinoma (cHCC-CCA), and to explore the differential therapeutic ben...