Shandong Tumor Hospital

NoiBic: a noise-tolerant biclustering algorithm for high-throughput gene expression data analysis

Abstract Motivation High-throughput transcriptomic technologies generate large-scale gene expression datasets for functional module discovery. However, technical and biological noise can obscure coherent expression patterns and compromise module detection. Noise-tolerant methods...

Macrophage-derived MMP14 fosters immunosuppressive tumor microenvironment by regulating soluble semaphorin 4D

Abstract High expression of semaphorin 4D (SEMA4D) in tumor cells fosters an immunosuppressive tumor microenvironment (TME), yet the underlying tumor-macrophage crosstalk remains poorly understood. Here, we investigated this regulatory axis using in vitro co-cultures and SEMA4D g...

Ultrasound-activatable bacteria for biomedical applications

Bacteria have emerged as powerful therapeutic vectors owing to their intrinsic tumour tropism, genetic programmability, and living therapeutic functions. However, the trade-off between their autonomous proliferation and potential immunotoxicity restricts their clinical translatio...

Integrating neuroimaging, transcriptomics and single-cell sequencing identifies candidate molecular features of cortical vulnerability in amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disease that leads to reductions in cortical surface area (SA) and thickness (TH). However, the genetic and molecular mechanisms underlying these cortical structural alterations remain unclear. This st...

Anti-cancer drug clinical research

Abstract Malignant tumors are major diseases that seriously threaten human health, and the unmet clinical demand for treatments in the field of oncology has been persistently large. The research and development of new antineoplastic drugs has become a powerful means to address th...

Cancer‐Associated Fibroblasts Promote Glucose Metabolic Reprogramming and Progression of Triple‐Negative Breast Cancer via Exosomal circFAD104‐Mediated Intercellular Communication

Triple-negative breast cancer (TNBC) is characterized by high metastatic tendency and poor prognosis, largely driven by dynamic crosstalk between cancer cells and the tumor microenvironment (TME). Cancer-associated fibroblasts (CAFs) are a major component of the TME, yet their fu...

Evidence-based recommendations for advancing the chronic pelvic pain syndrome management by the paradigm change from reactive symptom suppression to proactive 3PM-guided patient-centered care

Abstract Chronic pelvic pain syndrome (CPPS) encompasses a heterogeneous group of debilitating conditions including interstitial cystitis/bladder pain syndrome (IC/BPS), chronic abacterial prostatitis, endometriosis, and pelvic congestion syndrome, among others. Despite advances...

Early-life recurrent antibiotic use and risks of adult kidney cancer and sex-specific cancers: a prospective cohort study in the UK Biobank

There is little evidence about the associations of long-term or recurrent antibiotics use (LRAU) during early life with cancer risk. Our study aimed to assess the associations via Cox proportional hazards regression, using data from the UK Biobank (UKB). The main outcomes were th...

Fuzuloparib in combination with apatinib versus fuzuloparib alone for recurrent ovarian cancer: a randomized, open-label, phase 2 trial

A randomized, open-label, phase 2 trial assessed fuzuloparib (a PARP inhibitor) plus apatinib (a vascular endothelial growth factor receptor [VEGFR] inhibitor) versus fuzuloparib alone in patients with recurrent ovarian cancer (ROC). Patients with ROC who had failed ≥ 2 lines of...

CACA guidelines for the management of adult cancer pain

Abstract Cancer pain, one of the most prevalent and distressing symptoms in cancer patients, is closely associated with cancer diagnosis, therapeutic interventions, quality of life, and survival outcomes. Effective cancer pain management requires multidisciplinary collaborative a...

Randomized phase 2 trial of a PARP inhibitor TSL-1502 in germline BRCA-mutated, HER2-negative locally advanced/metastatic breast cancer

Glucuronide prodrug strategies may enhance target specificity and reduce the toxicity of PARP inhibitors, but no clinical evaluation has been performed. We evaluated TSL-1502, a novel glucuronide prodrug of a PARP inhibitor, in a randomized, open-label, phase 2 study at 28 sites...

Factors affecting job choices among primary health workers in China: a discrete choice experiment study

Primary health workers (PHWs) are crucial for primary health care, yet shortages and maldistribution persist in China. The study aimed to quantify their job preferences and the importance of key job attributes to inform attraction and retention policies. A discrete choice experim...

Targeting FibroblastActivation Protein for PrecisionMedicine

Conspectus The advancement of precision medicine depends critically on well-defined molecular targets. Pathologically activated fibroblasts drive disease progression in cancer, fibrosis and chronic inflammation through sustained inflammation, extracellular matrix remodeling and p...