Shandong Provincial QianFoShan Hospital

Development and validation of machine learning models for preoperative prediction of perioperative outcomes in patients with thymic epithelial tumors

Thymic epithelial tumors (TETs) are rare anterior mediastinal tumors with heterogeneous perioperative recovery. We developed and externally validated machine-learning models using preoperative and preoperatively available variables to predict postoperative complications, prolonge...

Direct oral anticoagulants versus vitamin K antagonists in cirrhotic portal vein thrombosis: a systematic review and meta-analysis of clinical, radiological, and safety outcomes

The optimal anticoagulant strategy for portal vein thrombosis (PVT) in patients with cirrhosis remains uncertain. This systematic review and meta-analysis compared the clinical, radiological, and safety outcomes associated with direct oral anticoagulants (DOACs) versus vitamin K...

NINJ2 alleviates inflammatory bowel disease by regulating the macrophage ZBP1-PANoptosis pathway

Abstract Inflammatory bowel disease (IBD) is a chronic, relapsing intestinal disorder with a complex etiology and incompletely understood pathogenesis, posing significant challenges for clinical management. The NINJ2 gene is located on chromosome 12, a region enriched with IBD su...

Multimorbidity patterns and domain-specific intrinsic capacity impairments among rural older adults: a multiple correspondence analysis and k-means clustering study

Abstract Background Multimorbidity is prevalent among older adults, but its specific patterns and differential associations with impairments across intrinsic capacity (IC) domains remain under-explored. This study aimed to identify stable multimorbidity patterns in rural older ad...

Predictors and prognostic stratification of bronchiolitis obliterans syndrome after pediatric allogeneic hematopoietic stem cell transplantation

Abstract Background Bronchiolitis Obliterans Syndrome (BOS) following pediatric allogeneic hematopoietic stem cell transplantation (allo-HSCT) is associated with high morbidity and mortality, largely due to diagnostic delays and static prognostic assessments. This study aimed to...

Development of a patient journey map for diabetic retinopathy: exploring evidence from qualitative research

The World Health Organization has emphasized people-centered health, shifting focus from disease to patient needs. Patient Journey Mapping has emerged as a valuable methodological approach to support healthcare and nursing management by visualizing patient experiences and identif...

Loss of LATS1 promotes immune evasion in colon cancer via YAP/TEAD-driven lactate metabolism reprogramming

Abstract The Hippo pathway components YAP and TAZ have been implicated in tumor immunity, but the role of upstream kinase LATS1 in colon cancer immune evasion remains unclear. This study aimed to investigate the function of LATS1 in regulating the tumor immune microenvironment (T...

Development and validation of a preoperative interpretable machine learning model for predicting myocardial injury following lung cancer surgery

Myocardial injury after non-cardiac surgery (MINS) is a common complication following lung cancer surgery and is associated with adverse prognostic outcomes. Preoperative cardiac risk assessment is essential for optimizing perioperative management and improving patient outcomes....