Shandong Provincial QianFoShan Hospital

Loss of LATS1 promotes immune evasion in colon cancer via YAP/TEAD-driven lactate metabolism reprogramming

Abstract The Hippo pathway components YAP and TAZ have been implicated in tumor immunity, but the role of upstream kinase LATS1 in colon cancer immune evasion remains unclear. This study aimed to investigate the function of LATS1 in regulating the tumor immune microenvironment (T...

Development and validation of a preoperative interpretable machine learning model for predicting myocardial injury following lung cancer surgery

Myocardial injury after non-cardiac surgery (MINS) is a common complication following lung cancer surgery and is associated with adverse prognostic outcomes. Preoperative cardiac risk assessment is essential for optimizing perioperative management and improving patient outcomes....