Shandong Maternal and Child Health Hospital

Heterologous gene expression of a bacterial dipeptidyl peptidase 4 in the thermophilic filamentous fungus Humicola insolens

The thermophilic filamentous fungus Humicola insolens is a rich reservoir of enzymes with broad application potential, owing to their thermostability and neutral pH optima. H. insolens is also distinguished in secreting abundant catalase. Despite this characteristic, its potentia...

A segmentation-guided CNN–Vision transformer feature fusion framework for multi-class breast ultrasound image classification

Breast ultrasound (BU) imaging is widely used for detecting breast abnormalities because it is cost-effective, non-invasive, and suitable for dense breast tissue. However, multi-class classification of BU images is considered a challenging task due to low contrast, speckle noise,...

A multiomics-clinical model to predict treatment response in psoriasis

Psoriasis is a chronic inflammatory skin disease with highly variable responses to biologic therapies. Predictive tools to guide personalized treatment remain an unmet clinical need. To develop and validate a multiomics-clinical model for predicting a 75% reduction in the Psorias...

MRI Tract‐Based Quantitative Susceptibility Mapping of Limbic White Matter Alterations in Preeclampsia

BACKGROUND: Preeclampsia is associated with long-term cerebrovascular and cognitive risk, but tract-level white matter (WM) involvement remains incompletely characterized. PURPOSE: To investigate whether preeclampsia is associated with tract-level WM susceptibility alterations on...

The deubiquitinase PSMD14 accelerates cervical cancer progression, with thiolutin offering a novel therapeutic approach

Abnormal function of deubiquitination enzymes is implicated in cancer progression. However, the role of the 26S proteasome non-ATPase regulatory subunit 14 (PSMD14) in cervical cancer development and its underlying mechanisms remain poorly understood. In our study, we evaluated t...

Biophysical reprogramming of immunosuppressive neutrophils by cold atmospheric plasma reinvigorates antitumor immunity

Neutrophils are increasingly recognized as key orchestrators of the immunosuppressive tumor microenvironment, yet their intrinsic plasticity, short lifespan and resistance to genetic manipulation have impeded therapeutic targeting. Here, we report a non-pharmacological, biophysic...