Shandong Institute of Food and Drug Inspection

An Integrated Strategy for Decoding Bioactive Components and Mechanism of Jingtong Granules: Chemical Characterization, Network Analysis, Pharmacokinetic and Pharmacodynamic Studies

This study aimed to identify bioactive constituents of Jingtong Granules (JTG), a traditional Chinese medicine for cervical spondylotic radiculopathy (CSR), characterize their in vivo exposure, and explore pharmacological targets and pathways. Chemical constituents were character...

Therapeutic Cancer Vaccines: Classification, Mechanisms, Challenges and Future Perspectives

BACKGROUND: With the rapid advancements in oncology, immunology, and molecular biology, immunotherapy has emerged as a cornerstone of anti-tumor treatment, complementing traditional modalities such as surgery, radiotherapy, and chemotherapy. Therapeutic cancer vaccines are a prom...

Molecular Networking-GuidedDiscovery of New Calbistrinsfrom Aspergillus japonicus and IntegratedOmics Analyses of Their Phytotoxic Mechanism

Abstract Fungal species are a rich source of bioactive metabolites for agrochemical discovery. LC-MS/MS-guided molecular networking of Aspergillus japonicus led to the isolation of eight rare calbistrin-type polyketides (1–8), including three new derivatives, japonidienes J–L (1–...