Shandong Eye Hospital

Combined Small Treatment Zone Orthokeratology and Alternate-Day 0.01% Atropine for Axial Elongation Control in Rapidly Progressing Myopic Children

Purpose: To evaluate the efficacy of small treatment zone (STZ) orthokeratology (ortho-K) combined with alternate-day 0.01% atropine to control axial elongation in rapidly progressing myopic children and identify associated optical predictors. Methods: This prospective randomized...

Systematic Analysis of Stromal-Epithelial Crosstalk Reveals the FGF21-FGFR3 Axis as a Key Driver of Corneal Wound Healing

Purpose: Corneal epithelial defects are a significant clinical problem and pose a severe threat to vision. However, their underlying mechanisms remain largely elusive. Here, we used single-cell RNA sequencing (scRNA-seq) and constructed cell-cell communication networks between co...

A PRK-armed oncolytic adenovirus drives calreticulin exposure for dendritic cell licensing to prime antitumor CD8⁺ T cells and synergizes with anti-PD-1 or CAR-T therapy in colorectal cancer

Abstract Background The therapeutic potential of oncolytic adenoviruses (ADVs) in colorectal cancer is constrained by a counterproductive host response: virus-triggered hyperactivation of the pro-survival AKT pathway, which fosters an immunosuppressive tumor microenvironment. Met...

PEBP1 Regulates Ferroptosis in Acute Glaucoma: Targeted Therapy Using Engineered Exosomes

Glaucoma is the leading cause of irreversible blindness worldwide, primarily driven by the progressive loss of retinal ganglion cells (RGCs) under pathological high intraocular pressure (ph-IOP). Despite the established role of ferroptosis in RGC degeneration, specific molecular...

Inflammation as a central mechanism: interactions among epithelial, immune, and neural units in dry eye disease and their therapeutic implications

Abstract Dry eye disease (DED) is a prevalent multifactorial ocular surface disorder. Early research primarily attributed its pathogenesis to insufficient tear secretion or excessive tear evaporation. Advances in mechanistic research have shifted the academic understanding from a...

The Matricellular Protein CCN1 Induces Corneal Stromal Cells Senescence and Inflammation to Trigger Extracellular Matrix Remodeling in Keratoconus

Purpose: Keratoconus (KC) is a multifactorial corneal degenerative disorder characterized by reduced extracellular matrix (ECM) and cellular content. This study investigates the role and mechanism of cellular communication network factor 1 (CCN1) in KC progression. Methods: The e...

Role of Autophagy in Scleral Remodeling During Form‐Deprivation Myopia

Autophagy has been implicated in tissue remodeling, but its role in scleral remodeling during myopia development and in atropine-mediated myopia control remains unclear. We investigated this issue using complementary in vitro and in vivo models. Human scleral fibroblasts (HSFs) w...

Different vault outcomes following implantable collamer lens implantation in eyes with ciliary body cysts: a case report

Ciliary body cysts are common incidental findings during preoperative screening for implantable collamer lens (ICL) implantation. Although their presence is generally not considered a contraindication to surgery, cysts extending into the ciliary sulcus may influence haptic seatin...