Shaheed Rajaei Cardiovascular Medical and Research Center

Geometric and morphological assessment of structurally normal tricuspid aortic valves based on body surface area using 3D transesophageal echocardiography

Aortic valve geometry is a key parameter for aortic valve repair, which serves as a surgical alternative to valve replacement for aortic insufficiency treatment. Individuals with different body sizes may exhibit varying geometric parameters of the aortic valve. This study aims to...

Coated or chewable Aspirin and a hybrid air pollution mitigation strategy in patients with atherosclerotic disease: Rationale and Design of the COATED-AIR Randomized Trial.

BACKGROUND: Although enteric-coated aspirin is widely used instead of chewable formulations in patients with atherosclerotic cardiovascular diseases (ASCVD), its effects on cardiovascular and gastrointestinal outcomes remain uncertain. Separately, air pollution is a driver of car...

Machine-learning prediction of cardiovascular diagnoses from pediatric ECG reports in 11 643 children

Cardiovascular disease (CVD) in children is heterogeneous, often paucisymptomatic, and easily missed at first contact, yet the electrocardiogram (ECG) remains the most widely available cardiac test. In routine care the ECG is stored and exchanged as a structured report rather tha...

Engineering CAR-NK cell platforms for breast cancer: metastatic interception, perioperative control, and emerging platelet-guided biomimetic strategies

Breast cancer metastasis remains the leading cause of disease-related mortality, highlighting the need for strategies that can intercept circulating tumor cells, suppress micrometastatic outgrowth, and eliminate residual disease during the perioperative window. Although CAR-T cel...

Platelet–NK cell interplay in advanced coronary artery disease is associated with pre-exhausted NK cell dysfunction without upregulation of the immune checkpoint receptor NKG2A

Platelet crosstalk with leukocytes plays a key role in the development of atherosclerosis. However, different immune cells are involved in the disease’s pathology, with Tregs showing protective effects against atherosclerosis, whereas NK cells appear to contribute to both atherog...

Platelet–neutrophil cooperation in premetastatic niche formation: from NETosis and stromal conditioning to nanotherapeutic interception

Metastasis remains the leading cause of cancer-related mortality, yet the metastatic cascade is initiated long before circulating tumor cells reach distant organs. Central to this early phase is the premetastatic niche (PMN), a dynamic and tumor-conditioned microenvironment in wh...

Comparison of the effect of suction catheter and nelaton catheter in airway suctioning on hemodynamic status of patients in intensive care units

Endotracheal suctioning is an essential procedure in mechanically ventilated patients to maintain airway patency and ensure adequate ventilation. Despite its regular use in intensive care units (ICUs), there is limited consensus on the ideal approach or preferred device. This stu...