Shaare Zedek Medical Center

A randomized phase II study of fulvestrant with or without ganetespib in patients with endocrine resistant metastatic breast cancer

Abstract Background Patients with endocrine-resistant hormone receptor-positive (HR+), HER2-negative metastatic breast cancer (MBC) have limited effective treatment options. Heat shock protein 90 (HSP90) regulates estrogen receptor stability and function; its inhibition has been...

The EnPlace® Device for Advanced Apical Prolapse: Anatomical Outcomes and Long-Term Satisfaction

Background: Apical pelvic organ prolapse remains a considerable surgical challenge given its comparatively high recurrence rates. The EnPlace® device provides a mesh-free, minimally invasive option for sacrospinous ligament fixation (SSLF). This study evaluates the long-term safe...

An international multicenter analysis of the outcome of pediatric first variceal hemorrhage

Background & Aims: Management of portal hypertension in children including primary prophylaxis of variceal bleeding is controversial due to limited understanding of mortality risk after first variceal hemorrhage (1VH). This international multicenter study was designed to advance...

Carbapenemase-producing Kluyvera spp.: epidemiology of an evolving species

Abstract Background Kluyvera spp. are increasingly recognised as significant pathogens in humans. Recent reports of carbapenemase-producing (CP) Kluyvera spp. raise a concern that they may be disseminating carbapenemases to other species undetected. Research on CP-Kluyvera spp. i...

Disability in pediatric inflammatory bowel diseases: A systematic review and a single center experience

OBJECTIVES: Toward development of a pediatric IBD disability index (PIDI), we aimed to review the literature on disability in pediatric inflammatory bowel disease (PIBD) and to estimate disability rates in a pediatric inception cohort. METHODS: A systematic review identified stud...

Metabolic heterogeneity in the risk of cancer among patients with cardiovascular diseases and diabetes

The co-occurrence of cardiovascular diseases (CVDs) and cancer may worsen patient outcomes and burden the healthcare system. We aimed to evaluate metabolic patterns of cancer risk and to characterize the heterogeneity of such an association across cancer and CVD subtypes. We anal...

Clinical usability of an explainable AI decision support tool and evaluation of multimodal models in NSCLC

Abstract Despite a decade in, immunotherapy (IO) treatment selection in non-small cell lung cancer (NSCLC) remains largely guided by subgroup analyses and imperfect programmed death ligand 1 (PD-L1) and clinical scores. To our knowledge, I 3 LUNG ( NCT05537922 ) is currently the...

Bacteremia Identified After Emergency Department Discharge in Adults: A Retrospective Analysis of Outcomes and Risk Factors

Background: Adults who undergo blood-culture sampling in the emergency department (ED) may be discharged before results are finalized and later found bacteremic. Factors identifying which patients require readmission are not well defined. We sought predictors of return and hospit...

From Rapid Progression to Long-Lasting Complete Response: A Wide Range of Ripretinib Activity for Metastatic GIST—A Real-World Cohort

Background: Ripretinib, a switch-control kinase inhibitor approved for advanced gastrointestinal stromal tumor (GIST), inhibits primary and secondary KIT and PDGFRA mutations. Real-world data from Western and Middle Eastern populations remain limited. We report outcomes from a mo...

Gestational diabetes in multifetal versus singleton pregnancies: A multicenter cohort study

Abstract Introduction Gestational diabetes mellitus (GDM) is associated with increased neonatal morbidity in singleton pregnancies, but evidence in multifetal pregnancies is limited. Current diagnostic thresholds are largely extrapolated from singleton data; It remains unclear wh...

Psychological, social, and ethical implications of population-based genetic testing among adults: a systematic scoping review protocol with a focus on cancer

The standard clinical genetic testing model for hereditary cancers applies stringent eligibility criteria and consistently misses large numbers of at-risk cancer-susceptibility-gene (CSG) carriers in the general population, leading to missed opportunities for cancer screening/pre...

Metabolic Dysfunction–Associated Steatotic Liver Disease: An Underrated and Emerging Cardiovascular Risk Factor

Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent chronic liver disease worldwide and is increasingly recognized as a major contributor to cardiovascular morbidity and mortality. Beyond liver involvement, MASLD represents a systemic metabolic...

Alignment between expanded carrier screening panels and conditions leading to PGT-M: a real-world cohort study

PURPOSE: To assess the extent to which expanded carrier screening (ECS) panels capture the genetic conditions for which preimplantation genetic testing for monogenic diseases (PGT-M) is performed. METHODS: A retrospective observational study conducted at a single university-affil...